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231225s2018 xx |||||o 00| ||eng c |
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|a 10.2166/wst.2018.255
|2 doi
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|a pubmed25n0955.xml
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Nunes, B
|e verfasserin
|4 aut
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|a Assessment of ecotoxicological effects of ciprofloxacin in Daphnia magna
|b life-history traits, biochemical and genotoxic effects
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|c 2018
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 01.11.2018
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|a Date Revised 15.12.2020
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|a published: Print
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|a Citation Status MEDLINE
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|a Antibiotics (e.g. ciprofloxacin) have been detected in surface water and groundwater for several decades. In order to understand the potential impact of the continuous exposure of aquatic organisms to ciprofloxacin, a chronic assay was carried out with Daphnia magna. This approach allowed evaluation of the effects of ciprofloxacin on life-history and sub-individual parameters (antioxidant status and metabolic response: activities of catalase and glutathione S-transferases - GSTs; peroxidative damage; thiobarbituric acid reactive substances and genotoxic effects (genetic damage index, measured by the comet assay). Life-history parameters of D. magna showed no significant effects after ciprofloxacin exposure. Concerning oxidative stress and metabolism parameters, no significant alterations were reported for catalase and GSTs activities. However, a dual response was observed, with a significant decrease in lipid peroxidation levels at low ciprofloxacin concentrations (<0.013 mg/L), while a significant increase was verified at high ciprofloxacin concentrations (0.078 mg/L). The genotoxicity assay detected a significant increase in genetic damage index up to 0.013 mg/L of ciprofloxacin. The here-tested ciprofloxacin concentrations, which are ecologically relevant, did not cause significant impacts concerning the life-history parameters of D. magna; however, at the same levels of ciprofloxacin an oxidative stress and genotoxic damage scenarios were recorded
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|a Journal Article
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|a Anti-Bacterial Agents
|2 NLM
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|a Antioxidants
|2 NLM
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|a Water Pollutants, Chemical
|2 NLM
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| 650 |
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|a Ciprofloxacin
|2 NLM
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| 650 |
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|a 5E8K9I0O4U
|2 NLM
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| 650 |
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|a Catalase
|2 NLM
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| 650 |
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|a EC 1.11.1.6
|2 NLM
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| 650 |
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|a Glutathione Transferase
|2 NLM
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| 650 |
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|a EC 2.5.1.18
|2 NLM
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| 700 |
1 |
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|a Leal, C
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Rodrigues, S
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Antunes, S C
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Water science and technology : a journal of the International Association on Water Pollution Research
|d 1986
|g 2017(2018), 3 vom: 25. Juli, Seite 835-844
|w (DE-627)NLM098149431
|x 0273-1223
|7 nnns
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| 773 |
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|g volume:2017
|g year:2018
|g number:3
|g day:25
|g month:07
|g pages:835-844
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|u http://dx.doi.org/10.2166/wst.2018.255
|3 Volltext
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