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231225s2018 xx |||||o 00| ||chi c |
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|a 10.3760/cma.j.issn.0578-1310.2018.07.012
|2 doi
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|a DE-627
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|e rakwb
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| 041 |
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|a chi
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| 100 |
1 |
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|a Tang, S P
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Correlation between severity of gastroesophageal reflux cough and degree of gastroesophageal reflux disease
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|c 2018
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|a Text
|b txt
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|a ƒaComputermedien
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|a Date Completed 01.04.2019
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|a Date Revised 01.04.2019
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|a published: Print
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|a Citation Status MEDLINE
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|a Objective: To explore the correlation between the severity of gastroesophageal reflux cough and degree of gastroesophageal reflux. Methods: A cross-sectional investigation was carried out. Data of 174 cases of chronic cough were collected in Children's Hospital of Fuzhou from March 2009 to December 2016. The esophageal 24 hours pH value dynamic monitoring was used to detect gastric acid reflux index. Cases with abnomal results were divided into mild, moderate and severe groups according to severity of reflux and that of day and night cough symptoms, respectively. They were also divided into infant (1-3 years old), preschool (4-6 years old), and school age (>7 years old) groups according to age. Comparative analysis between groups by chi-square test and rank sum test were performed. Correlation analysis was used to analyze the correlation between cough severity and gastroesophageal reflux index. Results: A total of 174 patients with chronic cough, including 115 males and 59 females, aged from 1 to 15 years with an average age of (8.5±2.3) years, and (1.6±0.8) years of disease duration were enrolled. Among them, 129 cases (74.1%) were positive for esophageal reflux test and 45 cases (25.9%) with no obvious pathological gastroesophageal reflux. Patients with positive esophageal reflux test were divided into severe (n=37, 28.7%), moderate (n=23, 17.8%), and mild (n=69, 53.5%). There was no significant difference in the distribution of gastroesophageal reflux in each age group. (The proportions of mild, moderate and severe reflux in infants were 45.0% (9/20), 25.0% (5/20), and 30.0% (6/20), respectively. The proportions of mild, moderate and severe reflux in preschool children were 53.3% (32/60), 16.7% (10/60), 30.0% (18/60), respectively. The proportions of mild, moderate and severe reflux in school age children were 57.1% (28/49), 16.3% (8/49), 26.5% (13/49), respectively χ(2)=1.204, P=0.877). There was no correlation between age group and gastroesophageal reflux (r=-0.065, P=0.489).The severity of nighttime cough was positively correlated with percentages of distal esophagus pH≤4 in time, recumbent pH≤4 in time, and DeMeester score<14.72 (r=0.689, 0.621, and 0.707 respectively, all P<0.05). There was no statistically significant correlation between the severity of nighttime cough symptoms and percentage of standing pH≤4 in time (r=0.113, P>0.05). There were no statistically significant correlation between the severity of daytime cough and all gastroesophageal reflux markers (all P>0.05). Conclusion: The severity of nocturnal symptoms of gastroesophageal reflux cough is related to the degree of gastroesophageal reflux, to which clinical pediatricians should pay attention
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|a Journal Article
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|a 24 hour esophagus pH monitoring
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|a Cough
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| 650 |
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|a Gastroesophageal reflux
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| 700 |
1 |
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|a Liu, Y L
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gao, H
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Dong, L
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lin, D R
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, S
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, D Y
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|4 aut
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| 700 |
1 |
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|a Zhang, L L
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| 700 |
1 |
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|a Pan, J
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| 773 |
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|i Enthalten in
|t Zhonghua er ke za zhi = Chinese journal of pediatrics
|d 1960
|g 56(2018), 7 vom: 02. Juli, Seite 534-538
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|g volume:56
|g year:2018
|g number:7
|g day:02
|g month:07
|g pages:534-538
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|u http://dx.doi.org/10.3760/cma.j.issn.0578-1310.2018.07.012
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