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231225s2018 xx |||||o 00| ||eng c |
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|a 10.1002/adma.201802546
|2 doi
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|a pubmed25n0954.xml
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|a (DE-627)NLM286282275
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|a (NLM)29985542
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
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|a Zhu, Shoujun
|e verfasserin
|4 aut
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|a Repurposing Cyanine NIR-I Dyes Accelerates Clinical Translation of Near-Infrared-II (NIR-II) Bioimaging
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|c 2018
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Revised 27.02.2024
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|a published: Print-Electronic
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|a Citation Status Publisher
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|a © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a The significantly reduced tissue autofluorescence and scattering in the NIR-II region (1000-1700 nm) opens many exciting avenues for detailed investigation of biological processes in vivo. However, the existing NIR-II fluorescent agents, including many molecular dyes and inorganic nanomaterials, are primarily focused on complicated synthesis routes and unknown immunogenic responses with limited potential for clinical translation. Herein, the >1000 nm tail emission of conventional biocompatible NIR cyanine dyes with emission peaks at 700-900 nm is systematically investigated, and a type of bright dye for NIR-II imaging with high potential for accelerating clinical translation is identified. The asymmetry of the π domain in the S1 state of NIR cyanine dyes is proven to result in a twisted intramolecular charge-transfer process and NIR-II emission, establishing a general rule to guide future NIR-I/II fluorophore synthesis. The screened NIR dyes are identified to possess a bright emission tail in the NIR-II region along with high quantum yield, high molar-extinction coefficient, rapid fecal excretion, and functional groups amenable for bioconjugation. As a result, NIR cyanine dyes can be used for NIR-II imaging to afford superior contrast and real-time imaging of several biological models, facilitating the translation of NIR-II bioimaging to clinical theranostic applications
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|a Journal Article
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|a NIR-I fluorophores
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|a NIR-II imaging
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|a cyanine dye
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|a emission tail
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|a tumor imaging
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|a Hu, Zhubin
|e verfasserin
|4 aut
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| 700 |
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|a Tian, Rui
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yung, Bryant C
|e verfasserin
|4 aut
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| 700 |
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|a Yang, Qinglai
|e verfasserin
|4 aut
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| 700 |
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|a Zhao, Su
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kiesewetter, Dale O
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Niu, Gang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sun, Haitao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Antaris, Alexander L
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Xiaoyuan
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g (2018) vom: 09. Juli, Seite e1802546
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
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|g year:2018
|g day:09
|g month:07
|g pages:e1802546
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|u http://dx.doi.org/10.1002/adma.201802546
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