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20240229161817.0 |
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231225s2018 xx |||||o 00| ||eng c |
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|a 10.1002/adma.201801317
|2 doi
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|a pubmed24n1308.xml
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|a DE-627
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|c DE-627
|e rakwb
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|a eng
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| 100 |
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|a Porto, Vanesa
|e verfasserin
|4 aut
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|a Silver Atomic Quantum Clusters of Three Atoms for Cancer Therapy
|b Targeting Chromatin Compaction to Increase the Therapeutic Index of Chemotherapy
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|c 2018
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Revised 27.02.2024
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|a published: Print-Electronic
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|a Citation Status Publisher
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|a © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a Nanomaterials with very low atomicity deserve consideration as potential pharmacological agents owing to their very small size and to their properties that can be precisely tuned with minor modifications to their size. Here, it is shown that silver clusters of three atoms (Ag3 -AQCs)-developed by an ad hoc method-augment chromatin accessibility. This effect only occurs during DNA replication. Coadministration of Ag3 -AQCs increases the cytotoxic effect of DNA-acting drugs on human lung carcinoma cells. In mice with orthotopic lung tumors, the coadministration of Ag3 -AQCs increases the amount of cisplatin (CDDP) bound to the tumor DNA by fivefold without modifying CDDP levels in normal tissues. As a result, CDDP coadministered with Ag3 -AQCs more strongly reduces the tumor burden. Evidence of the significance of targeting chromatin compaction to increase the therapeutic index of chemotherapy is now provided
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|a Journal Article
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|a DNA-binding drugs
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|a atomic quantum clusters
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|a cancer therapy
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|a chromatin accessibility
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|a silver clusters
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|a Borrajo, Erea
|e verfasserin
|4 aut
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|a Buceta, David
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|a Carneiro, Carmen
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|a Huseyinova, Shahana
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|a Domínguez, Blanca
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|a Borgman, Kyra J E
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|a Lakadamyali, Melike
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|a Garcia-Parajo, Maria F
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|a Neissa, José
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|a García-Caballero, Tomás
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|a Barone, Giampaolo
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|a Blanco, M Carmen
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|a Busto, Natalia
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|a García, Begoña
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|a Leal, José Maria
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|a Blanco, José
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|a Rivas, José
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|a López-Quintela, M Arturo
|e verfasserin
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|a Domínguez, Fernando
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g (2018) vom: 03. Juli, Seite e1801317
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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|g year:2018
|g day:03
|g month:07
|g pages:e1801317
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|u http://dx.doi.org/10.1002/adma.201801317
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