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231225s2018 xx |||||o 00| ||eng c |
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|a 10.1002/adma.201802373
|2 doi
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|a pubmed24n0953.xml
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Myerson, Jacob W
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Flexible Nanoparticles Reach Sterically Obscured Endothelial Targets Inaccessible to Rigid Nanoparticles
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|c 2018
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 26.02.2019
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|a Date Revised 21.07.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a Molecular targeting of nanoparticle drug carriers promises maximized therapeutic impact to sites of disease or injury with minimized systemic effects. Precise targeting demands addressing to subcellular features. Caveolae, invaginations in cell membranes implicated in transcytosis and inflammatory signaling, are appealing subcellular targets. Caveolar geometry has been reported to impose a ≈50 nm size cutoff on nanocarrier access to plasmalemma vesicle associated protein (PLVAP), a marker found in caveolae in the lungs. The use of deformable nanocarriers to overcome that size cutoff is explored in this study. Lysozyme-dextran nanogels (NGs) are synthesized with ≈150 or ≈300 nm mean diameter. Atomic force microscopy indicates the NGs deform on complementary surfaces. Quartz crystal microbalance data indicate that NGs form softer monolayers (≈60 kPa) than polystyrene particles (≈8 MPa). NGs deform during flow through microfluidic channels, and modeling of NG extrusion through porous filters yields sieving diameters less than 25 nm for NGs with 150 and 300 nm hydrodynamic diameters. NGs of 150 and 300 nm diameter target PLVAP in mouse lungs while counterpart rigid polystyrene particles do not. The data in this study indicate a role for mechanical deformability in targeting large high-payload drug-delivery vehicles to sterically obscured targets like PLVAP
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|a Journal Article
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|a cell biology
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|a functional nanoparticles
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|a nanogels
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| 650 |
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|a nanomechanics
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|a nanomedicine
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|a Drug Carriers
|2 NLM
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| 650 |
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|a Polyethylene Glycols
|2 NLM
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| 650 |
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7 |
|a 3WJQ0SDW1A
|2 NLM
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| 650 |
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|a Polyethyleneimine
|2 NLM
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| 650 |
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7 |
|a 9002-98-6
|2 NLM
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| 700 |
1 |
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|a Braender, Bruce
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mcpherson, Olivia
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Glassman, Patrick M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kiseleva, Raisa Y
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shuvaev, Vladimir V
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Marcos-Contreras, Oscar
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Grady, Martha E
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lee, Hyun-Su
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Greineder, Colin F
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Stan, Radu V
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Composto, Russell J
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Eckmann, David M
|e verfasserin
|4 aut
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| 700 |
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|a Muzykantov, Vladimir R
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 30(2018), 32 vom: 30. Aug., Seite e1802373
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
1 |
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|g volume:30
|g year:2018
|g number:32
|g day:30
|g month:08
|g pages:e1802373
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| 856 |
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|u http://dx.doi.org/10.1002/adma.201802373
|3 Volltext
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