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231225s2018 xx |||||o 00| ||eng c |
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|a 10.1002/adma.201801622
|2 doi
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|a pubmed24n0952.xml
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|a (DE-627)NLM285707574
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|a (NLM)29926990
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Zheng, Di-Wei
|e verfasserin
|4 aut
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| 245 |
1 |
2 |
|a A Simply Modified Lymphocyte for Systematic Cancer Therapy
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1 |
|c 2018
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 25.09.2018
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a Cytotherapy has received considerable attention in the field of cancer therapy, and various chemical or genetic methods have been applied to remold natural cells for improved therapeutic outcome of cytotherapy. A simple method to modify lymphocytes for cancer treatment by using a clinically used molecule, δ-aminolevulinic acid (δ-ALA), is reported here. After incubation with this molecule, tumor-targeted lymphocytes spontaneously synthesize anti-neoplastic drug protoporphyrin X (PpIX), and specifically accumulate in cancer tissue. Under periodic 630 nm laser irradiation, lymphocytes generate vesicle-like apoptotic body (Ab) containing the above-produced PpIX, and the facilitated delivery of PpIX from Ab makes an excellent therapeutic effect for Ras-mutated cancer cells under a second irradiation. Importantly, a microfluidic device is further fabricated to simplify cell sorting and drug synthesis with a one-step operation, which could promote generalization of this strategy. In vitro and in vivo studies confirm the success of such an easy-operated and global-regulated strategy for cancer therapy
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|a Journal Article
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4 |
|a biomimetic delivery systems
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|a cytotherapy
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| 650 |
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|a extracellular vesicles
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|a lymphocytes
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|a photodynamic therapy
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|a Levulinic Acids
|2 NLM
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| 650 |
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|a Photosensitizing Agents
|2 NLM
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| 650 |
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|a Protoporphyrins
|2 NLM
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| 650 |
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|a Reactive Oxygen Species
|2 NLM
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| 650 |
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|a Aminolevulinic Acid
|2 NLM
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| 650 |
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7 |
|a 88755TAZ87
|2 NLM
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| 650 |
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|a protoporphyrin IX
|2 NLM
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| 650 |
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7 |
|a C2K325S808
|2 NLM
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| 650 |
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7 |
|a ras Proteins
|2 NLM
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| 650 |
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7 |
|a EC 3.6.5.2
|2 NLM
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| 650 |
|
7 |
|a levulinic acid
|2 NLM
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| 650 |
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7 |
|a RYX5QG61EI
|2 NLM
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| 700 |
1 |
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|a Fan, Jin-Xuan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Xin-Hua
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Dong, Xue
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Pan, Pei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xu, Lu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Xian-Zheng
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 30(2018), 31 vom: 21. Aug., Seite e1801622
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
1 |
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|g volume:30
|g year:2018
|g number:31
|g day:21
|g month:08
|g pages:e1801622
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| 856 |
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|u http://dx.doi.org/10.1002/adma.201801622
|3 Volltext
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