Rapid Biofilm Eradication on Bone Implants Using Red Phosphorus and Near-Infrared Light

Rapid Biofilm Eradication on Bone Implants Using Red Phosphorus and Near-Infrared Light

© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 30(2018), 31 vom: 19. Aug., Seite e1801808
1. Verfasser: Tan, Lei (VerfasserIn)
Weitere Verfasser: Li, Jun, Liu, Xiangmei, Cui, Zhenduo, Yang, Xianjin, Zhu, Shengli, Li, Zhaoyang, Yuan, Xubo, Zheng, Yufeng, Yeung, Kelvin W K, Pan, Haobo, Wang, Xianbao, Wu, Shuilin
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2018
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article antibiofilm bone-implants osteogenic differentiation photothermal therapy red phosphorus Bone Substitutes Core Binding Factor Alpha 1 Subunit Peptides Singlet Oxygen mehr... 17778-80-2 Phosphorus 27YLU75U4W Titanium D1JT611TNE
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520 |a © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. 
520 |a Bone-implant-associated infections are common after orthopedic surgery due to impaired host immune response around the implants. In particular, when a biofilm develops, the immune system and antibiotic treatment find it difficult to eradicate, which sometimes requires a second operation to replace the infected implants. Most strategies have been designed to prevent biofilms from forming on the surface of bone implants, but these strategies cannot eliminate the biofilm when it has been established in vivo. To address this issue, a nonsurgical, noninvasive treatment for biofilm infection must be developed. Herein, a red-phosphorus-IR780-arginine-glycine-aspartic-acid-cysteine coating on titanium bone implants is prepared. The red phosphorus has great biocompatibility and exhibits efficient photothermal ability. The temperature sensitivity of Staphylococcus aureus biofilm is enhanced in the presence of singlet oxygen (1 O2 ) produced by IR780. Without damaging the normal tissue, the biofilm can be eradicated through a safe near-infrared (808 nm) photothermal therapy at 50 °C in vitro and in vivo. This approach reaches an antibacterial efficiency of 96.2% in vivo with 10 min of irradiation at 50 °C. Meanwhile, arginine-glycine-aspartic-acid-cysteine decorated on the surface of the implant can improve the cell adhesion, proliferation, and osteogenic differentiation 
650 4 |a Journal Article 
650 4 |a antibiofilm 
650 4 |a bone-implants 
650 4 |a osteogenic differentiation 
650 4 |a photothermal therapy 
650 4 |a red phosphorus 
650 7 |a Bone Substitutes  |2 NLM 
650 7 |a Core Binding Factor Alpha 1 Subunit  |2 NLM 
650 7 |a Peptides  |2 NLM 
650 7 |a Singlet Oxygen  |2 NLM 
650 7 |a 17778-80-2  |2 NLM 
650 7 |a Phosphorus  |2 NLM 
650 7 |a 27YLU75U4W  |2 NLM 
650 7 |a Titanium  |2 NLM 
650 7 |a D1JT611TNE  |2 NLM 
700 1 |a Li, Jun  |e verfasserin  |4 aut 
700 1 |a Liu, Xiangmei  |e verfasserin  |4 aut 
700 1 |a Cui, Zhenduo  |e verfasserin  |4 aut 
700 1 |a Yang, Xianjin  |e verfasserin  |4 aut 
700 1 |a Zhu, Shengli  |e verfasserin  |4 aut 
700 1 |a Li, Zhaoyang  |e verfasserin  |4 aut 
700 1 |a Yuan, Xubo  |e verfasserin  |4 aut 
700 1 |a Zheng, Yufeng  |e verfasserin  |4 aut 
700 1 |a Yeung, Kelvin W K  |e verfasserin  |4 aut 
700 1 |a Pan, Haobo  |e verfasserin  |4 aut 
700 1 |a Wang, Xianbao  |e verfasserin  |4 aut 
700 1 |a Wu, Shuilin  |e verfasserin  |4 aut 
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773 1 8 |g volume:30  |g year:2018  |g number:31  |g day:19  |g month:08  |g pages:e1801808 
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