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231225s2018 xx |||||o 00| ||eng c |
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|a 10.1111/nph.15249
|2 doi
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|a pubmed25n0951.xml
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|a (DE-627)NLM285419900
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|a (NLM)29897620
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Yuan, Rongrong
|e verfasserin
|4 aut
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| 245 |
1 |
4 |
|a The Arabidopsis USL1 controls multiple aspects of development by affecting late endosome morphology
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|c 2018
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 25.09.2019
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2018 The Authors. New Phytologist © 2018 New Phytologist Trust.
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|a The polar transport of auxin controls many aspects of plant development. However, the molecular mechanisms underlying auxin tranport regulation remain to be further elucidated. We identified a mutant named as usl1 (unflattened and small leaves) in a genetic screen in Arabidopsis thaliana. The usl1 displayed multiple aspects of developmental defects in leaves, embryogenesis, cotyledons, silique phyllotaxy and lateral roots in addition to abnormal leaves. USL1 encodes a protein orthologous to the yeast vacuolar protein sorting (Vps) 38p and human UV RADIATION RESISTANCE-ASSOCIATED GENE (UVRAG). Cell biology, Co-IP/MS and yeast two-hybrid were used to identify the function of USL1. USL1 colocalizes at the subcellular level with VPS29, a key factor of the retromer complex that controls auxin transport. The morphology of the VPS29-associated late endosomes (LE) is altered from small dots in the wild-type to aberrant enlarged circles in the usl1 mutants. The usl1 mutant synergistically interacts with vps29. We also found that USL1 forms a complex with AtVPS30 and AtVPS34. We propose that USL1 controls multiple aspects of plant development by affecting late endosome morphology and by regulating the PIN1 polarity. Our findings provide a new layer of the understanding on the mechanisms of plant development regulation
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Arabidopsis thaliana
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|a AtVPS30
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| 650 |
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|a AtVPS34 complex
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| 650 |
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|a USL1
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4 |
|a VPS29
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|a auxin transport
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| 650 |
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|a endocytic trafficking
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|a late endosome
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|a Arabidopsis Proteins
|2 NLM
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|a Membrane Transport Proteins
|2 NLM
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| 650 |
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|a PIN1 protein, Arabidopsis
|2 NLM
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| 650 |
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|a VPS38 protein, Arabidopsis
|2 NLM
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| 650 |
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|a Vesicular Transport Proteins
|2 NLM
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| 650 |
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|a Phosphatidylinositol 3-Kinases
|2 NLM
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| 650 |
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7 |
|a EC 2.7.1.-
|2 NLM
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| 700 |
1 |
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|a Lan, Jingqiu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fang, Yuxing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yu, Hao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Jinzhe
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Huang, Jiaying
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Qin, Genji
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t The New phytologist
|d 1979
|g 219(2018), 4 vom: 22. Sept., Seite 1388-1405
|w (DE-627)NLM09818248X
|x 1469-8137
|7 nnas
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| 773 |
1 |
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|g volume:219
|g year:2018
|g number:4
|g day:22
|g month:09
|g pages:1388-1405
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| 856 |
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|u http://dx.doi.org/10.1111/nph.15249
|3 Volltext
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|d 219
|j 2018
|e 4
|b 22
|c 09
|h 1388-1405
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