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231225s2018 xx |||||o 00| ||eng c |
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|a 10.1002/adma.201800316
|2 doi
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|a eng
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| 100 |
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|a Jiang, Yu
|e verfasserin
|4 aut
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| 245 |
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|a Protein Toxin Chaperoned by LRP-1-Targeted Virus-Mimicking Vesicles Induces High-Efficiency Glioblastoma Therapy In Vivo
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|c 2018
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|a Text
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|a ƒaComputermedien
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|a Date Completed 07.03.2019
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|a Date Revised 09.01.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a Glioblastoma is a most intractable and high-mortality malignancy because of its extremely low drug accessibility resulting from the blood-brain barrier (BBB). Here, it is reported that angiopep-2-directed and redox-responsive virus-mimicking polymersomes (ANG-PS) (angiopep-2 is a peptide targeting to low-density lipoprotein receptor-related protein-1 (LRP-1)) can efficiently and selectively chaperone saporin (SAP), a highly potent natural protein toxin, to orthotopic human glioblastoma xenografts in nude mice. Unlike chemotherapeutics, free SAP has a low cytotoxicity. SAP-loaded ANG-PS displays, however, a striking antitumor activity (half-maximal inhibitory concentration, IC50 = 30.2 × 10-9 m) toward U-87 MG human glioblastoma cells in vitro as well as high BBB transcytosis and glioblastoma accumulation in vivo. The systemic administration of SAP-loaded ANG-PS to U-87 MG orthotopic human-glioblastoma-bearing mice brings about little side effects, effective tumor inhibition, and significantly improved survival rate. The protein toxins chaperoned by LRP-1-targeted virus-mimicking vesicles emerge as a novel and highly promising treatment modality for glioblastoma
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|a Journal Article
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|a angiopep-2
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|a blood-brain barrier
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|a glioblastoma
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| 650 |
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4 |
|a polymersomes
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| 650 |
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4 |
|a therapeutic proteins
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| 700 |
1 |
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|a Yang, Weijing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Jian
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Meng, Fenghua
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhong, Zhiyuan
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 30(2018), 30 vom: 03. Juli, Seite e1800316
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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|g volume:30
|g year:2018
|g number:30
|g day:03
|g month:07
|g pages:e1800316
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|u http://dx.doi.org/10.1002/adma.201800316
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