perfectBASH : Band-selective homonuclear decoupling in peptides and peptidomimetics
© 2018 John Wiley & Sons, Ltd.
| Veröffentlicht in: | Magnetic resonance in chemistry : MRC. - 1985. - 56(2018), 10 vom: 08. Okt., Seite 918-933 |
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| Format: | Online-Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2018
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| Zugriff auf das übergeordnete Werk: | Magnetic resonance in chemistry : MRC |
| Schlagworte: | Journal Article Research Support, Non-U.S. Gov't 1H-NMR 2D NMR NMR band-selective homonuclear (BASH) decoupling full sensitivity peptides peptidomimetics perfect echo mehr... |
| Zusammenfassung: | © 2018 John Wiley & Sons, Ltd. Band selective techniques offer the highest sensitivity of all pure shift approaches and thus are the best choice for decoupling well-separated 1 H-frequency regions, such as the amide- or the α-proton region of α-peptides. They are inept to fully decouple the amide- and the α-proton region simultaneously, though. Herein, we present a new homonuclear decoupling technique, which extends the capabilities of band selective decoupling using the perfect echo principle. This modification allows a complete backbone decoupling (amide- and α-protons) in peptides and opens band selective homonuclear decoupling to substances with two mutually coupled protons in the spectral range of interest |
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| Beschreibung: | Date Completed 27.08.2019 Date Revised 27.08.2019 published: Print-Electronic Citation Status MEDLINE |
| ISSN: | 1097-458X |
| DOI: | 10.1002/mrc.4757 |