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231225s2018 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2018.06.001
|2 doi
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|a pubmed24n0950.xml
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|a (DE-627)NLM285283715
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|a (NLM)29883708
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|a (PII)S1521-6616(18)30262-6
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Tanko, Ramla F
|e verfasserin
|4 aut
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|a Residual T cell activation and skewed CD8+ T cell memory differentiation despite antiretroviral therapy-induced HIV suppression
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|c 2018
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 27.08.2019
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|a Date Revised 31.03.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2018 Elsevier Inc. All rights reserved.
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|a HIV infection results in excessive T cell activation and dysfunction which may persist even during effective antiretroviral therapy (ART). The dynamics of immune 'deactivation' and extent to which T cell memory subsets normalize after ART are unclear. We longitudinally assessed the influence of 1 year of ART on the phenotype of T cells in HIV-infected African women, relative to matched HIV-uninfected women, using activation (CD38, HLA-DR) and differentiation markers (CD27, CD45RO). ART induced a substantial reduction in T cell activation, but remained higher than HIV-uninfected controls. ART largely normalized the distribution of CD4+ T cell memory subsets, while the distribution of CD8+ T cell memory subsets remained significantly skewed compared to HIV-uninfected individuals. Thus, there was a considerable but only partial reversal of T cell defects upon ART. Understanding T cell impairment may provide important insights into mechanisms of HIV pathogenesis in the era of ART
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| 650 |
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|a Journal Article
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| 650 |
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|a Research Support, N.I.H., Extramural
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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4 |
|a Research Support, U.S. Gov't, Non-P.H.S.
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| 650 |
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|a Antiretroviral therapy
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| 650 |
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4 |
|a Chronic HIV
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| 650 |
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|a T cell activation
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| 650 |
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4 |
|a T cell differentiation
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| 650 |
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|a Antibodies, Viral
|2 NLM
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| 700 |
1 |
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|a Soares, Andreia P
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Masson, Lindi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Garrett, Nigel J
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Samsunder, Natasha
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Abdool Karim, Quarraisha
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Abdool Karim, Salim S
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Riou, Catherine
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Burgers, Wendy A
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 195(2018) vom: 01. Okt., Seite 127-138
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:195
|g year:2018
|g day:01
|g month:10
|g pages:127-138
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|u http://dx.doi.org/10.1016/j.clim.2018.06.001
|3 Volltext
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|d 195
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