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231225s2018 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2018.05.004
|2 doi
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2 |
|a pubmed24n0949.xml
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|a (DE-627)NLM284883581
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|a (NLM)29842946
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|a (PII)S1521-6616(18)30246-8
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Lingampalli, Nithya
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Combination of anti-citrullinated protein antibodies and rheumatoid factor is associated with increased systemic inflammatory mediators and more rapid progression from preclinical to clinical rheumatoid arthritis
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|c 2018
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 27.08.2019
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| 500 |
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|a Date Revised 29.04.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2018. Published by Elsevier Inc.
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|a The development of rheumatoid factor (RF) and/or anti-citrullinated protein antibodies (ACPAs) can be observed years prior to clinical diagnosis of rheumatoid arthritis (RA). Nevertheless, the interaction between these two autoantibodies and their combined effect on development of RA is unclear. We measured RF, cytokines, and ACPA subtypes in serial pre-clinical serum samples collected from 83 US veterans who all developed RA. Levels of cytokines and ACPAs were compared between the following groups: anti-cyclic citrullinated peptide (anti-CCP)-/RF- (double negative), anti-CCP+/RF-, anti-CCP-/RF+, or anti-CCP+/RF+ (double-positive). The double-positive subgroup had significantly higher levels of 20 inflammatory cytokines and 29 ACPA reactivities, and the shortest interval, 1.3 years, between the preclinical sample timepoint and diagnosis of RA. Thus, the combined presence of ACPAs and RF is associated with a more rapid progression to RA, suggesting that anti-CCP+/RF+ individuals have a more advanced preclinical disease state and that the onset of RA may be imminent
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, N.I.H., Extramural
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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4 |
|a Anti-citrullinated protein antibodies (ACPA)
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| 650 |
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4 |
|a Cytokines
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| 650 |
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4 |
|a Rheumatoid arthritis
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| 650 |
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4 |
|a Rheumatoid factor (RF)
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| 650 |
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7 |
|a Anti-Citrullinated Protein Antibodies
|2 NLM
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| 650 |
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7 |
|a Cytokines
|2 NLM
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| 650 |
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7 |
|a Epitopes, B-Lymphocyte
|2 NLM
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| 650 |
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7 |
|a Inflammation Mediators
|2 NLM
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| 650 |
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7 |
|a Rheumatoid Factor
|2 NLM
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| 650 |
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7 |
|a 9009-79-4
|2 NLM
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| 700 |
1 |
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|a Sokolove, Jeremy
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lahey, Lauren J
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Edison, Jess D
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gilliland, William R
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Holers, V Michael
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Deane, Kevin D
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Robinson, William H
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 195(2018) vom: 25. Okt., Seite 119-126
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:195
|g year:2018
|g day:25
|g month:10
|g pages:119-126
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2018.05.004
|3 Volltext
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|d 195
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