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20240229161657.0 |
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231225s2018 xx |||||o 00| ||eng c |
| 024 |
7 |
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|a 10.1002/adma.201801198
|2 doi
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|a pubmed24n1308.xml
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|a (DE-627)NLM284540633
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|a (NLM)29808576
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Shao, Dan
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Bioinspired Diselenide-Bridged Mesoporous Silica Nanoparticles for Dual-Responsive Protein Delivery
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|c 2018
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Revised 27.02.2024
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|a published: Print-Electronic
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|a Citation Status Publisher
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| 520 |
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|a © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a Controlled delivery of protein therapeutics remains a challenge. Here, the inclusion of diselenide-bond-containing organosilica moieties into the framework of silica to fabricate biodegradable mesoporous silica nanoparticles (MSNs) with oxidative and redox dual-responsiveness is reported. These diselenide-bridged MSNs can encapsulate cytotoxic RNase A into the 8-10 nm internal pores via electrostatic interaction and release the payload via a matrix-degradation controlled mechanism upon exposure to oxidative or redox conditions. After surface cloaking with cancer-cell-derived membrane fragments, these bioinspired RNase A-loaded MSNs exhibit homologous targeting and immune-invasion characteristics inherited from the source cancer cells. The efficient in vitro and in vivo anti-cancer performance, which includes increased blood circulation time and enhanced tumor accumulation along with low toxicity, suggests that these cell-membrane-coated, dual-responsive degradable MSNs represent a promising platform for the delivery of bio-macromolecules such as protein and nucleic acid therapeutics
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|a Journal Article
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4 |
|a biodegradable mesoporous silica nanoparticles
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| 650 |
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4 |
|a cancer-cell-membrane cloaking
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| 650 |
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4 |
|a diselenide
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| 650 |
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4 |
|a dual-responsive
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| 650 |
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4 |
|a protein delivery
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| 700 |
1 |
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|a Li, Mingqiang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Zheng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zheng, Xiao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lao, Yeh-Hsing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chang, Zhimin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Fan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lu, Mengmeng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yue, Juan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hu, Hanze
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yan, Huize
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Li
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Dong, Wen-Fei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Leong, Kam W
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g (2018) vom: 28. Mai, Seite e1801198
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
1 |
8 |
|g year:2018
|g day:28
|g month:05
|g pages:e1801198
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| 856 |
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|u http://dx.doi.org/10.1002/adma.201801198
|3 Volltext
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|a GBV_ILN_350
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|a AR
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|j 2018
|b 28
|c 05
|h e1801198
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