Bright Aggregation-Induced-Emission Dots for Targeted Synergetic NIR-II Fluorescence and NIR-I Photoacoustic Imaging of Orthotopic Brain Tumors

© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - (2018) vom: 28. Mai, Seite e1800766
1. Verfasser: Sheng, Zonghai (VerfasserIn)
Weitere Verfasser: Guo, Bing, Hu, Dehong, Xu, Shidang, Wu, Wenbo, Liew, Weng Heng, Yao, Kui, Jiang, Jingying, Liu, Chengbo, Zheng, Hairong, Liu, Bin
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2018
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article NIR-II fluorescence imaging aggregation-induced emission brain tumors nanoparticles photoacoustic imaging
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520 |a Precise diagnostics are of significant importance to the optimal treatment outcomes of patients bearing brain tumors. NIR-II fluorescence imaging holds great promise for brain-tumor diagnostics with deep penetration and high sensitivity. This requires the development of organic NIR-II fluorescent agents with high quantum yield (QY), which is difficult to achieve. Herein, the design and synthesis of a new NIR-II fluorescent molecule with aggregation-induced-emission (AIE) characteristics is reported for orthotopic brain-tumor imaging. Encapsulation of the molecule in a polymer matrix yields AIE dots showing a very high QY of 6.2% with a large absorptivity of 10.2 L g-1 cm-1 at 740 nm and an emission maximum near 1000 nm. Further decoration of the AIE dots with c-RGD yields targeted AIE dots, which afford specific and selective tumor uptake, with a high signal/background ratio of 4.4 and resolution up to 38 µm. The large NIR absorptivity of the AIE dots facilitates NIR-I photoacoustic imaging with intrinsically deeper penetration than NIR-II fluorescence imaging and, more importantly, precise tumor-depth detection through intact scalp and skull. This research demonstrates the promise of NIR-II AIE molecules and their dots in dual NIR-II fluorescence and NIR-I photoacoustic imaging for precise brain cancer diagnostics 
650 4 |a Journal Article 
650 4 |a NIR-II fluorescence imaging 
650 4 |a aggregation-induced emission 
650 4 |a brain tumors 
650 4 |a nanoparticles 
650 4 |a photoacoustic imaging 
700 1 |a Guo, Bing  |e verfasserin  |4 aut 
700 1 |a Hu, Dehong  |e verfasserin  |4 aut 
700 1 |a Xu, Shidang  |e verfasserin  |4 aut 
700 1 |a Wu, Wenbo  |e verfasserin  |4 aut 
700 1 |a Liew, Weng Heng  |e verfasserin  |4 aut 
700 1 |a Yao, Kui  |e verfasserin  |4 aut 
700 1 |a Jiang, Jingying  |e verfasserin  |4 aut 
700 1 |a Liu, Chengbo  |e verfasserin  |4 aut 
700 1 |a Zheng, Hairong  |e verfasserin  |4 aut 
700 1 |a Liu, Bin  |e verfasserin  |4 aut 
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773 1 8 |g year:2018  |g day:28  |g month:05  |g pages:e1800766 
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