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231225s2018 xx |||||o 00| ||eng c |
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|a 10.1002/adma.201800766
|2 doi
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|a pubmed24n1308.xml
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|a (DE-627)NLM284517283
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|a (NLM)29806179
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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|a Sheng, Zonghai
|e verfasserin
|4 aut
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|a Bright Aggregation-Induced-Emission Dots for Targeted Synergetic NIR-II Fluorescence and NIR-I Photoacoustic Imaging of Orthotopic Brain Tumors
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|c 2018
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Revised 27.02.2024
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|a published: Print-Electronic
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|a Citation Status Publisher
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|a © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a Precise diagnostics are of significant importance to the optimal treatment outcomes of patients bearing brain tumors. NIR-II fluorescence imaging holds great promise for brain-tumor diagnostics with deep penetration and high sensitivity. This requires the development of organic NIR-II fluorescent agents with high quantum yield (QY), which is difficult to achieve. Herein, the design and synthesis of a new NIR-II fluorescent molecule with aggregation-induced-emission (AIE) characteristics is reported for orthotopic brain-tumor imaging. Encapsulation of the molecule in a polymer matrix yields AIE dots showing a very high QY of 6.2% with a large absorptivity of 10.2 L g-1 cm-1 at 740 nm and an emission maximum near 1000 nm. Further decoration of the AIE dots with c-RGD yields targeted AIE dots, which afford specific and selective tumor uptake, with a high signal/background ratio of 4.4 and resolution up to 38 µm. The large NIR absorptivity of the AIE dots facilitates NIR-I photoacoustic imaging with intrinsically deeper penetration than NIR-II fluorescence imaging and, more importantly, precise tumor-depth detection through intact scalp and skull. This research demonstrates the promise of NIR-II AIE molecules and their dots in dual NIR-II fluorescence and NIR-I photoacoustic imaging for precise brain cancer diagnostics
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|a Journal Article
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|a NIR-II fluorescence imaging
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|a aggregation-induced emission
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|a brain tumors
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|a nanoparticles
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|a photoacoustic imaging
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|a Guo, Bing
|e verfasserin
|4 aut
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|a Hu, Dehong
|e verfasserin
|4 aut
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|a Xu, Shidang
|e verfasserin
|4 aut
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|a Wu, Wenbo
|e verfasserin
|4 aut
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|a Liew, Weng Heng
|e verfasserin
|4 aut
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|a Yao, Kui
|e verfasserin
|4 aut
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|a Jiang, Jingying
|e verfasserin
|4 aut
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|a Liu, Chengbo
|e verfasserin
|4 aut
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|a Zheng, Hairong
|e verfasserin
|4 aut
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|a Liu, Bin
|e verfasserin
|4 aut
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g (2018) vom: 28. Mai, Seite e1800766
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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|g year:2018
|g day:28
|g month:05
|g pages:e1800766
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|u http://dx.doi.org/10.1002/adma.201800766
|3 Volltext
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