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231225s2018 xx |||||o 00| ||eng c |
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|a 10.1002/adma.201707240
|2 doi
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|a pubmed24n0947.xml
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|a eng
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| 100 |
1 |
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|a Zhang, Xiao
|e verfasserin
|4 aut
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| 245 |
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|a Virion-Like Membrane-Breaking Nanoparticles with Tumor-Activated Cell-and-Tissue Dual-Penetration Conquer Impermeable Cancer
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|c 2018
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|a Text
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|a ƒaComputermedien
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|a Date Completed 06.03.2019
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a Poor drug penetration into tumor cells and tissues is a worldwide difficulty in cancer therapy. A strategy is developed for virion-like membrane-breaking nanoparticles (MBNs) to smoothly accomplish tumor-activated cell-and-tissue dual-penetration for surmounting impermeable drug-resistant cancer. Tailor-made dendritic arginine-rich peptide prodrugs are designed to mimic viral protein transduction domains and globular protein architectures. Attractively, these protein mimics self-assemble into virion-like nanoparticles in aqueous solution, having highly ordered secondary structure. Tumor-specific acidity conditions would activate the membrane-breaking ability of these virion-like nanoparticles to perforate artificial and natural membrane systems. As expected, MBNs achieve highly efficient drug penetration into drug-resistant human ovarian (SKOV3/R) cancer cells. Most importantly, the well-organized MBNs can pass through endothelial/tumor cells and spread from one cell to another one. Intravenous injection of MBNs into nude mice bearing impermeable SKOV3/R tumors suggests that the MBNs can recognize the tumor tissue after prolonged blood circulation, evoke the membrane-breaking function for robust transvascular extravasation, and penetrate into the deep tumor tissue. This work provides the first demonstration of sophisticated molecular and supramolecular engineering of virion-like MBNs to realize the long-awaited cell-and-tissue dual-penetration, contributing to the development of a brand-new avenue for dealing with incurable cancers
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|a Journal Article
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|a impermeable cancer
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|a membrane-breaking capacity
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|a multidrug resistance reversal
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|a tumor penetration
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| 650 |
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4 |
|a virion-like nanoparticles
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| 650 |
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7 |
|a Peptides
|2 NLM
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| 700 |
1 |
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|a Xu, Xianghui
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Yachao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hu, Cheng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Zhijun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gu, Zhongwei
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 30(2018), 27 vom: 17. Juli, Seite e1707240
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|g volume:30
|g year:2018
|g number:27
|g day:17
|g month:07
|g pages:e1707240
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|u http://dx.doi.org/10.1002/adma.201707240
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