Alginate-Mediated Mineralization for Ultrafine Hydroxyapatite Hybrid Nanoparticles
The good bioactivity of hydroxyapatite (HA) makes it become a popular biomaterial, and so, the synthesis of HA has attracted much attention. However, a simple method to prepare well-dispersive and ultrafine HA nanoparticles (NPs) still needs to be explored. Here, needle-like hybrid HA NPs were synth...
| Veröffentlicht in: | Langmuir : the ACS journal of surfaces and colloids. - 1985. - 34(2018), 23 vom: 12. Juni, Seite 6797-6805 |
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| 1. Verfasser: | |
| Weitere Verfasser: | , , , , , , , |
| Format: | Online-Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2018
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| Zugriff auf das übergeordnete Werk: | Langmuir : the ACS journal of surfaces and colloids |
| Schlagworte: | Journal Article Research Support, Non-U.S. Gov't |
| Zusammenfassung: | The good bioactivity of hydroxyapatite (HA) makes it become a popular biomaterial, and so, the synthesis of HA has attracted much attention. However, a simple method to prepare well-dispersive and ultrafine HA nanoparticles (NPs) still needs to be explored. Here, needle-like hybrid HA NPs were synthesized in the presence of alginate (ALG) and the mechanism of ALG regulation on forming HA/ALG hybrid NPs was investigated. The size and crystallinity of HA/ALG NPs could be controlled simply by varying the amount of ALG. With a higher concentration of ALG, the size of HA/ALG NPs reduced and their dispersity was further improved. The assembly with ca. 3-6 nm thick nanoneedles was discernible in HA/ALG NPs. The results collected by Ca2+ concentration, pH, and conductometric measurements further provided the supportive data for ALG inhibition of calcium phosphate compound formation and thus modulation of HA crystallization. In addition, the good biocompatibility of synthesized HA/ALG NPs was indicated from the results of CCK-8 assays and CLSM observations after cultured with L929 cells. The needle-like HA NPs are promising for varied biomedical purposes, and their potential application as drug carriers would be further studied |
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| Beschreibung: | Date Completed 17.09.2018 Date Revised 10.04.2022 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
| ISSN: | 1520-5827 |
| DOI: | 10.1021/acs.langmuir.8b00151 |