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231225s2018 xx |||||o 00| ||eng c |
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|a 10.1007/s10646-018-1941-5
|2 doi
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|a pubmed24n0946.xml
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|a (DE-627)NLM283914971
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|a (NLM)29744622
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
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|a López Aca, Viviana
|e verfasserin
|4 aut
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| 245 |
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|a Lethal and sublethal responses in the fish, Odontesthes bonariensis, exposed to chlorpyrifos alone or under mixtures with endosulfán and lambda-cyhalothrin
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|c 2018
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 11.12.2018
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Need for ecotoxicological information on local species has been recently highlighted as a priority issue in Latin America. In addition, little information has been found on concentration distances between lethal and sublethal effects, and the effect of mixtures at these two levels of analysis. Chlorpyrifos (CPF) is an organophosphate insecticide broadly used in soybean crops which has dramatically expanded in Latin America and other regions of the world. The aim of the present study was to evaluate lethal and sublethal effects of CPF, singly or in mixtures, on the inland "Pejerrey" (Odontesthes bonariensis) under laboratory conditions. Bioassays were performed using 15-30 d post hatch Pejerrey larvae. Six toxicity tests were run for estimating the average inter-assay dose-response curve of CPF and other six for assessing the effects of mixtures of CPF with endosulfan (EN) or lambda-cyhalothrin (LC), at three toxic units (TU) proportions (25:75, 50:50, 75:25). In addition, four assays were performed to describe the average inter-assay dose-response inhibition curve of acetylcholinesterase (AchE) for CPF alone and two for assessing the mixtures. The estimated 96 h-LC50 for CPF was 2.26 ± 1.11 µg/L and the incipiency value was 0.048 ± 0.012 µg/L, placing this Neotropical species among the 13% of worldwide fish more sensitive to CPF. In addition, the 96 h-LC50 for EN and LC were 0.30 ± 0.012 µg/L and 0.043 ± 0.031 µg/L, respectively. Therefore, relative toxicity of the three soybean insecticides for O. bonariensis was LC > EN > CPF. Effects of mixtures with EN and LC were variable, but in general fitted to both, independent action (IA) and concentration addition (CA) models. Slight antagonism was found when CPF TU proportions were above 50%. Therefore, from the regulatory point of view, the use of both mixture models, CA or IA, would be precautionary. Differential sensitivity to CPF was found for AchE inhibition at the head (96 h-IC50 = 0.065 ± 0.058 µg/L) and the body (96 h-IC50 = 0.48 ± 0.17 µg/L). In addition, whereas no significant effects induced by mixtures was observed in body AchE activity, antagonism was induced in head AchE inhibition in presence of both, EN and LC in the mixture. The lethal to sublethal ratio was close to 25.2 and 3.4 when comparing the CPF-LC50 and IC50s for head and body AchE activity, respectively. However, considerable overlapping was observed between concentration-response curves, indicating that the use of AchE as biomarker for environmental monitoring would be limited
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|a Journal Article
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|a AchE
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|a Ecotoxicology
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| 650 |
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|a LC50
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|a Mextures
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| 650 |
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|a O. bonariensis
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| 650 |
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|a Pesticides
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|a Cholinesterase Inhibitors
|2 NLM
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| 650 |
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7 |
|a Insecticides
|2 NLM
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| 650 |
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|a Water Pollutants, Chemical
|2 NLM
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| 650 |
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7 |
|a Chlorpyrifos
|2 NLM
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| 650 |
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7 |
|a JCS58I644W
|2 NLM
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| 650 |
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7 |
|a Endosulfan
|2 NLM
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| 650 |
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|a OKA6A6ZD4K
|2 NLM
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| 700 |
1 |
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|a Gonzalez, Patricia Verónica
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Carriquiriborde, Pedro
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Ecotoxicology (London, England)
|d 1992
|g 27(2018), 7 vom: 09. Sept., Seite 968-979
|w (DE-627)NLM098212214
|x 1573-3017
|7 nnns
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| 773 |
1 |
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|g volume:27
|g year:2018
|g number:7
|g day:09
|g month:09
|g pages:968-979
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| 856 |
4 |
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|u http://dx.doi.org/10.1007/s10646-018-1941-5
|3 Volltext
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