Molecular Cancer Imaging in the Second Near-Infrared Window Using a Renal-Excreted NIR-II Fluorophore-Peptide Probe

Molecular Cancer Imaging in the Second Near-Infrared Window Using a Renal-Excreted NIR-II Fluorophore-Peptide Probe

© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 30(2018), 22 vom: 02. Mai, Seite e1800106
1. Verfasser: Wang, Weizhi (VerfasserIn)
Weitere Verfasser: Ma, Zhuoran, Zhu, Shoujun, Wan, Hao, Yue, Jingying, Ma, Huilong, Ma, Rui, Yang, Qinglai, Wang, Zihua, Li, Qian, Qian, Yixia, Yue, Chunyan, Wang, Yuehua, Fan, Linyang, Zhong, Yeteng, Zhou, Ying, Gao, Hongpeng, Ruan, Junshan, Hu, Zhiyuan, Liang, Yongye, Dai, Hongjie
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2018
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article molecular imaging peptide probe renal-excretion second near-infrared window tumor targeting Fluorescent Dyes Peptides
LEADER 01000caa a22002652 4500
001 NLM283307498
003 DE-627
005 20240716231903.0
007 cr uuu---uuuuu
008 231225s2018 xx |||||o 00| ||eng c
024 7 |a 10.1002/adma.201800106  |2 doi 
028 5 2 |a pubmed24n1472.xml 
035 |a (DE-627)NLM283307498 
035 |a (NLM)29682821 
040 |a DE-627  |b ger  |c DE-627  |e rakwb 
041 |a eng 
100 1 |a Wang, Weizhi  |e verfasserin  |4 aut 
245 1 0 |a Molecular Cancer Imaging in the Second Near-Infrared Window Using a Renal-Excreted NIR-II Fluorophore-Peptide Probe 
264 1 |c 2018 
336 |a Text  |b txt  |2 rdacontent 
337 |a ƒaComputermedien  |b c  |2 rdamedia 
338 |a ƒa Online-Ressource  |b cr  |2 rdacarrier 
500 |a Date Completed 07.03.2019 
500 |a Date Revised 16.07.2024 
500 |a published: Print-Electronic 
500 |a Citation Status MEDLINE 
520 |a © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. 
520 |a In vivo molecular imaging of tumors targeting a specific cancer cell marker is a promising strategy for cancer diagnosis and imaging guided surgery and therapy. While targeted imaging often relies on antibody-modified probes, peptides can afford targeting probes with small sizes, high penetrating ability, and rapid excretion. Recently, in vivo fluorescence imaging in the second near-infrared window (NIR-II, 1000-1700 nm) shows promise in reaching sub-centimeter depth with microscale resolution. Here, a novel peptide (named CP) conjugated NIR-II fluorescent probe is reported for molecular tumor imaging targeting a tumor stem cell biomarker CD133. The click chemistry derived peptide-dye (CP-IRT dye) probe afforded efficient in vivo tumor targeting in mice with a high tumor-to-normal tissue signal ratio (T/NT > 8). Importantly, the CP-IRT probes are rapidly renal excreted (≈87% excretion within 6 h), in stark contrast to accumulation in the liver for typical antibody-dye probes. Further, with NIR-II emitting CP-IRT probes, urethra of mice can be imaged fluorescently for the first time noninvasively through intact tissue. The NIR-II fluorescent, CD133 targeting imaging probes are potentially useful for human use in the clinic for cancer diagnosis and therapy 
650 4 |a Journal Article 
650 4 |a molecular imaging 
650 4 |a peptide probe 
650 4 |a renal-excretion 
650 4 |a second near-infrared window 
650 4 |a tumor targeting 
650 7 |a Fluorescent Dyes  |2 NLM 
650 7 |a Peptides  |2 NLM 
700 1 |a Ma, Zhuoran  |e verfasserin  |4 aut 
700 1 |a Zhu, Shoujun  |e verfasserin  |4 aut 
700 1 |a Wan, Hao  |e verfasserin  |4 aut 
700 1 |a Yue, Jingying  |e verfasserin  |4 aut 
700 1 |a Ma, Huilong  |e verfasserin  |4 aut 
700 1 |a Ma, Rui  |e verfasserin  |4 aut 
700 1 |a Yang, Qinglai  |e verfasserin  |4 aut 
700 1 |a Wang, Zihua  |e verfasserin  |4 aut 
700 1 |a Li, Qian  |e verfasserin  |4 aut 
700 1 |a Qian, Yixia  |e verfasserin  |4 aut 
700 1 |a Yue, Chunyan  |e verfasserin  |4 aut 
700 1 |a Wang, Yuehua  |e verfasserin  |4 aut 
700 1 |a Fan, Linyang  |e verfasserin  |4 aut 
700 1 |a Zhong, Yeteng  |e verfasserin  |4 aut 
700 1 |a Zhou, Ying  |e verfasserin  |4 aut 
700 1 |a Gao, Hongpeng  |e verfasserin  |4 aut 
700 1 |a Ruan, Junshan  |e verfasserin  |4 aut 
700 1 |a Hu, Zhiyuan  |e verfasserin  |4 aut 
700 1 |a Liang, Yongye  |e verfasserin  |4 aut 
700 1 |a Dai, Hongjie  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Advanced materials (Deerfield Beach, Fla.)  |d 1998  |g 30(2018), 22 vom: 02. Mai, Seite e1800106  |w (DE-627)NLM098206397  |x 1521-4095  |7 nnns 
773 1 8 |g volume:30  |g year:2018  |g number:22  |g day:02  |g month:05  |g pages:e1800106 
856 4 0 |u http://dx.doi.org/10.1002/adma.201800106  |3 Volltext 
912 |a GBV_USEFLAG_A 
912 |a SYSFLAG_A 
912 |a GBV_NLM 
912 |a GBV_ILN_350 
951 |a AR 
952 |d 30  |j 2018  |e 22  |b 02  |c 05  |h e1800106