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231225s2018 xx |||||o 00| ||eng c |
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|a 10.5713/ajas.17.0900
|2 doi
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|a pubmed25n0942.xml
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|a (NLM)29642663
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|a DE-627
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|e rakwb
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|a eng
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|a Jecminkova, Katerina
|e verfasserin
|4 aut
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|a Association of leptin, toll-like receptor 4, and chemokine receptor of interleukin 8 C-X-C motif single nucleotide polymorphisms with fertility traits in Czech Fleckvieh cattle
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|c 2018
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Revised 29.09.2020
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|a published: Print-Electronic
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|a Citation Status PubMed-not-MEDLINE
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|a OBJECTIVE: The use of genetic markers can help to enhance reproduction in cattle, which is a very important trait for profitability in dairy production systems. This study evaluated the association between genotypes of leptin (LEP), toll-like receptor 4 (TLR4), and chemokine receptor of interleukin 8 C-X-C motif (CXCR1) genes and fertility traits in Czech Fleckvieh cattle
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|a METHODS: Phenotypic data from 786 Czech Fleckvieh cows raised on 5 farms in the Czech Republic were used, along with information from the 1st three parities. To determine genotype, the polymerase chain reaction- restriction fragment length polymorphism method was used
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|a RESULTS: Except for LEP g.-963C>T, all studied genotype frequencies of single nucleotide polymorphisms (SNPs) were distributed according to the Hardy-Weinberg equilibrium. Two LEP SNPs (g.-963C>T and c.357C>T) were associated with the age at the 1st calving, days open (DO), pregnancy rate after 1st service (PR), and calving interval (CLI). In LEP g.-963C>T the TT genotype heifers firstly calved 24 days earlier than CC genotype and the CT genotype cow showed a tendency for shorter DO and higher PR. In LEP c.357C>T we observed longer CLI and DO period in TT cows. In general, we can propose the TT genotype of g.-963C>T as favorable and the TT genotype of c.357C>T as unfavorable for a cow´s fertility. Heterozygotes in TLR4 c.-226C>G were significantly associated with shorter CLI, and presented a nonsignificant tendency to be associated with higher PR. In CXCR1 c.777 C>G, we did not observe any relationship of this SNP with reproduction
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|a CONCLUSION: Overall, the results showed that LEP could be an effective marker for improving reproduction in Czech Fleckvieh cattle. This study also provides novel insights into the relationship between TLR4 and CXCR1 SNPs and reproduction in dual-purpose cattle
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|a Journal Article
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|a Chemokine Receptor of Interleukin 8 C-X-C Motif
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|a Cow
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| 650 |
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|a Leptin
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|a Polymorphism
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| 650 |
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|a Reproduction
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| 650 |
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|a Toll-like Receptor 4
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| 700 |
1 |
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|a Müller, Uwe
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kyselova, Jitka
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sztankoova, Zuzana
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zavadilova, Ludmila
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Stipkova, Miloslava
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Majzlik, Ivan
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Asian-Australasian journal of animal sciences
|d 1998
|g 31(2018), 11 vom: 10. Nov., Seite 1721-1728
|w (DE-627)NLM098195883
|x 1011-2367
|7 nnns
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| 773 |
1 |
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|g volume:31
|g year:2018
|g number:11
|g day:10
|g month:11
|g pages:1721-1728
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| 856 |
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|u http://dx.doi.org/10.5713/ajas.17.0900
|3 Volltext
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