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231225s2018 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2018.03.015
|2 doi
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|a pubmed25n0941.xml
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|a (DE-627)NLM282584242
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|a (NLM)29608971
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|a (PII)S1521-6616(17)30595-8
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Moro-García, Marco Antonio
|e verfasserin
|4 aut
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| 245 |
1 |
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|a More intensive CMV-infection in chronic heart failure patients contributes to higher T-lymphocyte differentiation degree
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|c 2018
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 01.07.2019
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|a Date Revised 01.07.2019
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a Copyright © 2018 Elsevier Inc. All rights reserved.
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|a Immunosenescence in chronic heart failure (CHF) is characterized by a high frequency of differentiated T-lymphocytes, contributing to an inflammatory status and a deficient ability to generate immunocompetent responses. CMV is the best known inducer of T-lymphocyte differentiation, and is associated with the phenomenon of immunosenescence. In this study, we included 58 elderly chronic heart failure patients (ECHF), 60 healthy elderly controls (HEC), 40 young chronic heart failure patients (YCHF) and 40 healthy young controls (HYC). High differentiation of CD8+ T-lymphocytes was found in CMV-seropositive patients; however, the differentiation of CD4+ T-lymphocytes was increased in CMV-seropositive but also in CHF patients. Anti-CMV antibody titers showed positive correlation with more differentiated CD4+ and CD8+ subsets and inverse correlation with CD4/CD8 ratio. Immunosenescence found in CHF patients is mainly due to the dynamics of CMV-infection, since the differentiation of T-lymphocyte subsets is related not only to CMV-infection, but also to anti-CMV antibody titers
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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4 |
|a Aging
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| 650 |
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4 |
|a Antigens
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| 650 |
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4 |
|a CMV
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| 650 |
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4 |
|a Heart failure
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| 650 |
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4 |
|a Inflammation
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| 650 |
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4 |
|a Lymphocytes
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| 650 |
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7 |
|a Antibodies, Viral
|2 NLM
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| 700 |
1 |
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|a López-Iglesias, Fernando
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Marcos-Fernández, Raquel
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bueno-García, Eva
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Díaz-Molina, Beatriz
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lambert, José Luis
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Suárez-García, Francisco Manuel
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Morís de la Tassa, Cesar
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Alonso-Arias, Rebeca
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 192(2018) vom: 15. Juli, Seite 20-29
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:192
|g year:2018
|g day:15
|g month:07
|g pages:20-29
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2018.03.015
|3 Volltext
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|a GBV_USEFLAG_A
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|a SYSFLAG_A
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 192
|j 2018
|b 15
|c 07
|h 20-29
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