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|a 10.1016/j.clim.2018.03.014
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|a eng
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|a Carnero-Montoro, Elena
|e verfasserin
|4 aut
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| 245 |
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|a Epigenome-wide association studies for systemic autoimmune diseases
|b The road behind and the road ahead
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|c 2018
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|a Text
|b txt
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|a ƒaComputermedien
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|a Date Completed 14.10.2019
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|a Date Revised 14.10.2019
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2018 Elsevier Inc. All rights reserved.
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|a Epigenetics is known to be an important mechanism in the pathogenesis of autoimmune diseases. Epigenetic variations can act as integrators of environmental and genetic exposures and propagate activated states in immune cells. Studying epigenetic alterations by means of genome-wide approaches promises to unravel novel molecular mechanisms related to disease etiology, disease progression, clinical manifestations and treatment responses. This paper reviews what we have learned in the last five years from epigenome-wide studies for three systemic autoimmune diseases, namely systemic lupus erythematosus, primary Sjögren's syndrome, and rheumatoid arthritis. We examine the degree of epigenetic sharing between different diseases and the possible mediating role of epigenetic associations in genetic and environmental risks. Finally, we also shed light into the use of epigenetic markers towards a better precision medicine regarding disease prediction, prevention and personalized treatment in systemic autoimmunity
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Review
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|a Alarcón-Riquelme, Marta E
|e verfasserin
|4 aut
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|t Clinical immunology (Orlando, Fla.)
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|g 196(2018) vom: 01. Nov., Seite 21-33
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|g year:2018
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|g month:11
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