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01000naa a22002652 4500 |
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cr uuu---uuuuu |
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231225s2018 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2018.03.007
|2 doi
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|a pubmed24n0940.xml
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|a (DE-627)NLM282229205
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|a (NLM)29567431
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|a (PII)S1521-6616(18)30081-0
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Bahrami, Shervin
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Immunomodulating peptides derived from different human endogenous retroviruses (HERVs) show dissimilar impact on pathogenesis of a multiple sclerosis animal disease model
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| 264 |
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1 |
|c 2018
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 05.07.2019
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| 500 |
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|a Date Revised 05.07.2019
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a Copyright © 2018 Elsevier Inc. All rights reserved.
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|a Retroviruses including Human Endogenous Retroviruses (HERVs), contain a conserved region with highly immunomodulatory functions in the transmembrane proteins in envelope gene (env) named immunosuppressive domain (ISU). In this report, we demonstrate that Env59-GP3 peptide holds therapeutic potential in a mouse model of myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE). The results show that this specific HERV-H derived ISU peptide, but not peptide derived from another env gene HERV-K, decreased the development of EAE in C57BL/6 mice, accompanied by reduced demyelination and inhibition of inflammatory cells. Moreover, here we tested the effect of peptides on macrophages differentiation. The treatment with Env59-GPS peptide modulate the pro-inflammatory M1 profile and anti-inflammatory M2 macrophages, being shown by inhibiting inflammatory M1 hallmark genes/cytokines expression and enhancing expression of M2 associated markers. These results demonstrate that Env59-GP3 ISU peptide has therapeutic potential in EAE possibly through inducing the polarization of M2 macrophages and inhibiting inflammatory responses
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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4 |
|a EAE
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| 650 |
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4 |
|a Endogenous retrovirus
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| 650 |
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4 |
|a Immunosuppression, macrophages
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| 650 |
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4 |
|a MS
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| 650 |
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4 |
|a Peptide
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| 650 |
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7 |
|a Immunosuppressive Agents
|2 NLM
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| 650 |
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7 |
|a Peptides
|2 NLM
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| 650 |
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7 |
|a Viral Envelope Proteins
|2 NLM
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| 700 |
1 |
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|a Gryz, Elzbieta Anna
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Graversen, Jonas Heilskov
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Troldborg, Anne
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Stengaard Pedersen, Kristian
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Laska, Magdalena Janina
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 191(2018) vom: 14. Juni, Seite 37-43
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:191
|g year:2018
|g day:14
|g month:06
|g pages:37-43
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| 856 |
4 |
0 |
|u http://dx.doi.org/10.1016/j.clim.2018.03.007
|3 Volltext
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| 912 |
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|a GBV_USEFLAG_A
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|a SYSFLAG_A
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|a GBV_NLM
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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|a GBV_ILN_350
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|a AR
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|d 191
|j 2018
|b 14
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|h 37-43
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