Reversible Self-Assembled Monolayers (rSAMs) as Robust and Fluidic Lipid Bilayer Mimics

Lipid bilayers, forming the outer barrier of cells, display a wide array of proteins and carbohydrates for modulating interfacial biological interactions. Formed by the spontaneous self-assembly of lipid molecules, these bilayers feature liquid crystalline order, while retaining a high degree of lat...

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Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1985. - 34(2018), 13 vom: 03. Apr., Seite 4107-4115
1. Verfasser: Yeung, Sing Yee (VerfasserIn)
Weitere Verfasser: Ederth, Thomas, Pan, Guoqing, Cicėnaitė, Judita, Cárdenas, Marité, Arnebrant, Thomas, Sellergren, Börje
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2018
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Lipid Bilayers Water 059QF0KO0R Ethylene Glycol FC72KVT52F
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520 |a Lipid bilayers, forming the outer barrier of cells, display a wide array of proteins and carbohydrates for modulating interfacial biological interactions. Formed by the spontaneous self-assembly of lipid molecules, these bilayers feature liquid crystalline order, while retaining a high degree of lateral mobility. Studies of these dynamic phenomena have been hampered by the fragility and instability of corresponding biomimetic cell membrane models. Here, we present the construct of a series of oligoethylene glycol-terminated reversible self-assembled monolayers (rSAMs) featuring lipid-bilayer-like fluidity, while retaining air and protein stability and resistance. These robust and ordered layers were prepared by simply immersing a carboxylic acid-terminated self-assembled monolayer into 5-50 μM aqueous ω-(4-ethylene glycol-phenoxy)-α-(4-amidinophenoxy)decane solutions. It is anticipated that this new class of robust and fluidic two-dimensional biomimetic surfaces will impact the design of rugged cell surface mimics and high-performance biosensors 
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700 1 |a Ederth, Thomas  |e verfasserin  |4 aut 
700 1 |a Pan, Guoqing  |e verfasserin  |4 aut 
700 1 |a Cicėnaitė, Judita  |e verfasserin  |4 aut 
700 1 |a Cárdenas, Marité  |e verfasserin  |4 aut 
700 1 |a Arnebrant, Thomas  |e verfasserin  |4 aut 
700 1 |a Sellergren, Börje  |e verfasserin  |4 aut 
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