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231225s2018 xx |||||o 00| ||eng c |
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|a 10.1002/adma.201703740
|2 doi
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|a eng
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|a Li, Wei
|e verfasserin
|4 aut
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|a Tailoring Porous Silicon for Biomedical Applications
|b From Drug Delivery to Cancer Immunotherapy
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|c 2018
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|a Text
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|a ƒaComputermedien
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|a Date Completed 07.03.2019
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|a Date Revised 30.03.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a In the past two decades, porous silicon (PSi) has attracted increasing attention for its potential biomedical applications. With its controllable geometry, tunable nanoporous structure, large pore volume/high specific surface area, and versatile surface chemistry, PSi shows significant advantages over conventional drug carriers. Here, an overview of recent progress in the use of PSi in drug delivery and cancer immunotherapy is presented. First, an overview of the fabrication of PSi with various geometric structures is provided, with particular focus on how the unique geometry of PSi facilitates its biomedical applications, especially for drug delivery. Second, surface chemistry and modification of PSi are discussed in relation to the strengthening of its performance in drug delivery and bioimaging. Emerging technologies for engineering PSi-based composites are then summarized. Emerging PSi advances in the context of cancer immunotherapy are also highlighted. Overall, very promising research results encourage further exploration of PSi for biomedical applications, particularly in drug delivery and cancer immunotherapy, and future translation of PSi into clinical applications
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|a Journal Article
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|a Review
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|a drug delivery
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|a immunotherapy
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|a nanomedicine
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|a porous silicon
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|a surface modification
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|a Silicon
|2 NLM
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|a Z4152N8IUI
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| 700 |
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|a Liu, Zehua
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|a Fontana, Flavia
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|a Ding, Yaping
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| 700 |
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|a Liu, Dongfei
|e verfasserin
|4 aut
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|a Hirvonen, Jouni T
|e verfasserin
|4 aut
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| 700 |
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|a Santos, Hélder A
|e verfasserin
|4 aut
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|t Advanced materials (Deerfield Beach, Fla.)
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|g 30(2018), 24 vom: 11. Juni, Seite e1703740
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