The effects of fluoxetine on attachment and righting behaviours in marine (Gibbula unbilicalis) and freshwater (Lymnea stagnalis) gastropods
Recent studies have highlighted that antidepressants such as the selective serotonin reuptake inhibitors (SSRIs) entering aquatic systems through wastewater discharges might impact organisms at environmentally relevant concentrations. In this study, two snail species (Gibbula unbilicalis and Lymnea...
| Veröffentlicht in: | Ecotoxicology (London, England). - 1992. - 27(2018), 4 vom: 09. Mai, Seite 477-484 |
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| Format: | Online-Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2018
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| Zugriff auf das übergeordnete Werk: | Ecotoxicology (London, England) |
| Schlagworte: | Journal Article Antidepressants Behaviour Gastropoda Mollusca SSRI Serotonin Uptake Inhibitors Water Pollutants, Chemical Fluoxetine 01K63SUP8D |
| Zusammenfassung: | Recent studies have highlighted that antidepressants such as the selective serotonin reuptake inhibitors (SSRIs) entering aquatic systems through wastewater discharges might impact organisms at environmentally relevant concentrations. In this study, two snail species (Gibbula unbilicalis and Lymnea stagnalis) representing the marine and freshwater environments were exposed to a large range of fluoxetine concentrations (1 ng L-1-1 mg L-1) and two distinct behaviours (foot detachment and righting time) were recorded. Fluoxetine significantly caused foot detachment only at the higher of the concentrations (1 mg L-1) in both species during the course of this short term 1.5 h and 4 h exposures. In this study, lowest observed effect concentrations (LOECs) for foot detachment fell repeatedly within the range for other gastropod snails exposed to fluoxetine. Fluoxetine effected righting times in a concentration dependant manner but only significantly within G. unbilicalis in the highest concentration. Reviewing existing data on the effects of antidepressants on a range of endpoints in gastropod molluscs reveals wide variability of results. The importance of publishing 'negative' and/or non-dramatic results to aid risk assessment are discussed along with the variability between antidepressants, model species, experimental designs and endpoints |
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| Beschreibung: | Date Completed 04.09.2018 Date Revised 07.12.2022 published: Print-Electronic Citation Status MEDLINE |
| ISSN: | 1573-3017 |
| DOI: | 10.1007/s10646-018-1919-3 |