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231225s2018 xx |||||o 00| ||eng c |
| 024 |
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|a 10.1107/S160057751701668X
|2 doi
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|a pubmed25n0938.xml
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|a DE-627
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|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Dullin, Christian
|e verfasserin
|4 aut
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| 245 |
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|a MÖNCH detector enables fast and low-dose free-propagation phase-contrast computed tomography of in situ mouse lungs
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|c 2018
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 30.09.2019
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|a Date Revised 30.09.2019
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Due to the complexity of the underlying pathomechanism, in vivo mouse lung-disease models continue to be of great importance in preclinical respiratory research. Longitudinal studies following the cause of a disease or evaluating treatment efficacy are of particular interest but challenging due to the small size of the mouse lung and the fast breathing rate. Synchrotron-based in-line phase-contrast computed tomography imaging has been successfully applied in lung research in various applications, but mostly at dose levels that forbid longitudinal in vivo studies. Here, the novel charge-integrating hybrid detector MÖNCH is presented, which enables imaging of mouse lungs at a pixel size of 25 µm, in less than 10 s and with an entrance dose of about 70 mGy, which therefore will allow longitudinal lung disease studies to be performed in mouse models
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|a Journal Article
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|a charge-integration detector
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|a low dose phase-contrast computed tomography
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| 650 |
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|a mouse-lung imaging
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| 700 |
1 |
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|a Albers, Jonas
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tromba, Giuliana
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Andrä, Marie
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ramilli, Marco
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bergamaschi, Anna
|e verfasserin
|4 aut
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| 773 |
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8 |
|i Enthalten in
|t Journal of synchrotron radiation
|d 1994
|g 25(2018), Pt 2 vom: 01. März, Seite 565-569
|w (DE-627)NLM09824129X
|x 1600-5775
|7 nnns
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| 773 |
1 |
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|g volume:25
|g year:2018
|g number:Pt 2
|g day:01
|g month:03
|g pages:565-569
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| 856 |
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|u http://dx.doi.org/10.1107/S160057751701668X
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