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231225s2018 xx |||||o 00| ||eng c |
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|a 10.1002/adma.201705980
|2 doi
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|a pubmed24n0937.xml
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|a eng
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| 100 |
1 |
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|a Jiang, Yuyan
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Dual-Peak Absorbing Semiconducting Copolymer Nanoparticles for First and Second Near-Infrared Window Photothermal Therapy
|b A Comparative Study
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|c 2018
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 01.08.2018
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status PubMed-not-MEDLINE
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|a © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a Near-infrared (NIR) light is widely used for noninvasive optical diagnosis and phototherapy. However, current research focuses on the first NIR window (NIR-I, 650-950 nm), while the second NIR window (NIR-II, 1000-1700 nm) is far less exploited. The development of the first organic photothermal nanoagent (SPNI-II ) with dual-peak absorption in both NIR windows and its utilization in photothermal therapy (PTT) are reported herein. Such a nanoagent comprises a semiconducting copolymer with two distinct segments that respectively and identically absorb NIR light at 808 and 1064 nm. With the photothermal conversion efficiency of 43.4% at 1064 nm generally higher than other inorganic nanomaterials, SPNI-II enables superior deep-tissue heating at 1064 nm over that at 808 nm at their respective safety limits. Model deep-tissue cancer PTT at a tissue depth of 5 mm validates the enhanced antitumor effect of SPNI-II when shifting laser irradiation from the NIR-I to the NIR-II window. The good biodistribution and facile synthesis of SPNI-II also allow it to be doped with an NIR dye for fluorescence-imaging-guided NIR-II PTT through systemic administration. Thus, this study paves the way for the development of new polymeric nanomaterials to advance phototherapy
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|a Journal Article
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|a cancer therapy
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|a photothermal therapy
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|a second near-infrared window
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| 650 |
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|a semiconducting polymer nanoparticles
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1 |
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|a Li, Jingchao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhen, Xu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xie, Chen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Pu, Kanyi
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 30(2018), 14 vom: 30. Apr., Seite e1705980
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
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|g volume:30
|g year:2018
|g number:14
|g day:30
|g month:04
|g pages:e1705980
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| 856 |
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|u http://dx.doi.org/10.1002/adma.201705980
|3 Volltext
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