|
|
|
|
| LEADER |
01000naa a22002652 4500 |
| 001 |
NLM280033044 |
| 003 |
DE-627 |
| 005 |
20231225024416.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231225s2018 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1002/adma.201704888
|2 doi
|
| 028 |
5 |
2 |
|a pubmed24n0933.xml
|
| 035 |
|
|
|a (DE-627)NLM280033044
|
| 035 |
|
|
|a (NLM)29341267
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Zhou, Lingyun
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Cross-Linking of Thiolated Paclitaxel-Oligo(p-phenylene vinylene) Conjugates Aggregates inside Tumor Cells Leads to "Chemical Locks" That Increase Drug Efficacy
|
| 264 |
|
1 |
|c 2018
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 07.03.2019
|
| 500 |
|
|
|a Date Revised 30.09.2020
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
|
| 520 |
|
|
|a How to reduce the resistance of certain tumor cells to paclitaxel (PTX) and related taxoid anticancer drugs is a major challenge for improving cure rates. An oligo(p-phenylenevinylene) unit with thiol groups and a PTX unit (OPV-S-PTX), which enhances drug efficacy and reverses resistance is thus designed. The mechanism involves diffusion of OPV-S-PTX into the cell, where π-π interactions lead to aggregation. Cross-linking of the aggregates via oxidation of thiol groups is favored in tumor cells because of the higher reactive oxygen species (ROS) concentration. Cross-linked aggregates "chemically lock" the multichromophore particle for a more persistent effect. The IC50 of OPV-S-PTX for tumor cell line A549 is reduced down to 0.33 × 10-9 m from that observed for PTX itself (41 × 10-9 m). Enhanced efficacy by OPV-S-PTX is proposed to proceed via acceleration of microtubule bundle formation. A549/T-inoculated xenograft mice experiments reveal suppression of tumor growth upon OPV-S-PTX treatment. Altogether, these results show that the internal cross-linking of OPV-S-PTX through ROS provides a means to discriminate between tumor and healthy cells and the formation of the chemically locked particles enhances drug efficacy and helps in reducing resistance
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a antitumor
|
| 650 |
|
4 |
|a assembly inside cells
|
| 650 |
|
4 |
|a chemical locks
|
| 650 |
|
4 |
|a drug resistance
|
| 650 |
|
4 |
|a supramolecular paclitaxel
|
| 650 |
|
7 |
|a Antineoplastic Agents
|2 NLM
|
| 650 |
|
7 |
|a Antineoplastic Agents, Phytogenic
|2 NLM
|
| 650 |
|
7 |
|a Micelles
|2 NLM
|
| 650 |
|
7 |
|a Polyvinyls
|2 NLM
|
| 650 |
|
7 |
|a oligo(p-phenylene vinylene)
|2 NLM
|
| 650 |
|
7 |
|a Paclitaxel
|2 NLM
|
| 650 |
|
7 |
|a P88XT4IS4D
|2 NLM
|
| 700 |
1 |
|
|a Lv, Fengting
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Liu, Libing
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Shen, Guizhi
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Yan, Xuehai
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Bazan, Guillermo C
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Wang, Shu
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 30(2018), 10 vom: 17. März
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
|
| 773 |
1 |
8 |
|g volume:30
|g year:2018
|g number:10
|g day:17
|g month:03
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1002/adma.201704888
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 30
|j 2018
|e 10
|b 17
|c 03
|