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DE-627 |
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cr uuu---uuuuu |
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231225s2018 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2017.12.012
|2 doi
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2 |
|a pubmed25n0931.xml
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|a (DE-627)NLM279531095
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|a (NLM)29289748
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|a (PII)S1521-6616(17)30757-X
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Yang, Liuyang
|e verfasserin
|4 aut
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| 245 |
1 |
2 |
|a A novel bivalent fusion vaccine induces broad immunoprotection against Staphylococcus aureus infection in different murine models
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| 264 |
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1 |
|c 2018
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 22.04.2019
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| 500 |
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|a Date Revised 22.04.2019
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| 500 |
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a Copyright © 2017. Published by Elsevier Inc.
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|a With more and more drug-resistant Staphylococcus aureus strains emerging in hospitals, there is an urgent need to develop an effective vaccine to combat S. aureus infection. In this study, we constructed a novel bivalent fusion vaccine, SpA-DKKAA-FnBPA37-507 (SF), based on the D domain of staphylococcal protein A (SpA) and the A domain of fibronectin-binding protein A (FnBPA). Immunisation with SF induced a more ideal protective effect compared with the single components alone in a sepsis model. It also showed broad immunoprotection against seven FnBPA isotypes. Vaccination with SF induced strong antibodies responses and Th1/Th17 polarized cellular responses. Further we demonstrated the protective effect of antibodies by the opsonophagocytic assay (OPA) and passive immunisation. Moreover, vaccination with SF showed protective efficacy in a murine pneumonia model and skin abscess model. These results suggest that SF can be regarded as a promising vaccine candidate for the prevention of S. aureus infections
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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4 |
|a Fibronectin-binding protein A (FnBPA)
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| 650 |
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4 |
|a Staphylococcal protein A (SpA)
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| 650 |
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4 |
|a Staphylococcus aureus
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| 650 |
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4 |
|a Vaccine
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| 650 |
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7 |
|a Antibodies, Bacterial
|2 NLM
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| 650 |
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7 |
|a Staphylococcal Protein A
|2 NLM
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| 650 |
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7 |
|a Vaccines
|2 NLM
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| 700 |
1 |
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|a Zhou, Heng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cheng, Ping
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yang, Yun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tong, Yanan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zuo, Qianfei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Feng, Qiang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zou, Quanming
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zeng, Hao
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 188(2018) vom: 15. März, Seite 85-93
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:188
|g year:2018
|g day:15
|g month:03
|g pages:85-93
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| 856 |
4 |
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|u http://dx.doi.org/10.1016/j.clim.2017.12.012
|3 Volltext
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 188
|j 2018
|b 15
|c 03
|h 85-93
|