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DE-627 |
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20231225022829.0 |
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231225s2018 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2017.12.005
|2 doi
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|a pubmed24n0931.xml
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|a (DE-627)NLM279380097
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|a (NLM)29274388
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|a (PII)S1521-6616(17)30656-3
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Rabani, Mariam
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a IL-21 dependent Granzyme B production of B-cells is decreased in patients with lupus nephritis
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| 264 |
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1 |
|c 2018
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 22.04.2019
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| 500 |
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|a Date Revised 22.04.2019
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a Copyright © 2017 Elsevier Inc. All rights reserved.
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|a OBJECTIVES: B-cells play a crucial role in the pathogenesis of lupus nephritis. Recently, a separate subset has been discovered characterized by expression of Granzyme B. The aim of this study is to investigate this subset in patients with systemic lupus erythematosus (SLE)
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| 520 |
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|a METHODS: Isolated PBMCs of SLE-patients (n=30) and healthy controls (n=21) were in vitro stimulated with CPG, IgG+IgM and IL-21. Patients were sub-grouped in patients with and without biopsy proven lupus nephritis. B-cells were analyzed for intracellular Granzyme B expression by flow cytometry
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| 520 |
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|a RESULTS: The strongest stimulus for Granzyme B secretion of B-cells was IgG+IgM in presence of IL-21. SLE-patients had a significant decreased percentage of Granzyme B+ B-cells in particular SLE-patients with active disease and with lupus nephritis
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|a CONCLUSIONS: The frequency of GrB+ producing B-cells is reduced in SLE patients. This may contribute to an imbalanced B-cell regulation towards effector B-cells which might promote the development of lupus nephritis
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4 |
|a Journal Article
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|a Research Support, Non-U.S. Gov't
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| 650 |
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4 |
|a Granzyme B
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| 650 |
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4 |
|a IL-21
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| 650 |
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4 |
|a Lupus nephritis
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| 650 |
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4 |
|a SLE
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| 650 |
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7 |
|a Antigens, CD19
|2 NLM
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| 650 |
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7 |
|a Immunoglobulin G
|2 NLM
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| 650 |
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|a Immunoglobulin M
|2 NLM
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| 650 |
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|a Interleukins
|2 NLM
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| 650 |
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7 |
|a Receptors, Interleukin-21
|2 NLM
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| 650 |
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7 |
|a Granzymes
|2 NLM
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| 650 |
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7 |
|a EC 3.4.21.-
|2 NLM
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| 650 |
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|a interleukin-21
|2 NLM
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| 650 |
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7 |
|a MKM3CA6LT1
|2 NLM
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| 700 |
1 |
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|a Wilde, Benjamin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hübbers, Katharina
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xu, Shilei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kribben, Andreas
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Witzke, Oliver
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Dolff, Sebastian
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 188(2018) vom: 08. März, Seite 45-51
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:188
|g year:2018
|g day:08
|g month:03
|g pages:45-51
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| 856 |
4 |
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|u http://dx.doi.org/10.1016/j.clim.2017.12.005
|3 Volltext
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|a GBV_USEFLAG_A
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|a SYSFLAG_A
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|a GBV_NLM
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 188
|j 2018
|b 08
|c 03
|h 45-51
|