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231225s2018 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.7b03664
|2 doi
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|a pubmed24n0930.xml
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|a (DE-627)NLM279255438
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|a (NLM)29261314
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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|a Mueller, Eva
|e verfasserin
|4 aut
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|a Dynamically Cross-Linked Self-Assembled Thermoresponsive Microgels with Homogeneous Internal Structures
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|c 2018
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 17.09.2018
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|a Date Revised 17.09.2018
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a The internal morphology of temperature-responsive degradable poly(N-isopropylacrylamide) (PNIPAM) microgels formed via an aqueous self-assembly process based on hydrazide and aldehyde-functionalized PNIPAM oligomers is investigated. A combination of surface force measurements, small angle neutron scattering (SANS), and ultrasmall angle neutron scattering (USANS) was used to demonstrate that the self-assembled microgels have a homogeneously cross-linked internal structure. This result is surprising given the sequential addition process used to fabricate the microgels, which was expected to result in a densely cross-linked shell-diffuse core structure. The homogeneous internal structure identified is also significantly different than conventional microgels prepared via precipitation polymerization, which typically exhibit a diffuse shell-dense core structure. The homogeneous structure is hypothesized to result from the dynamic nature of the hydrazone cross-linking chemistry used to couple with the assembly conditions chosen that promote polymer interdiffusion. The lack of an internal cross-linking gradient within these degradable and monodisperse microgels is expected to facilitate more consistent drug release over time, improved optical properties, and other potential application benefits
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Acrylic Resins
|2 NLM
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|a Gels
|2 NLM
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|a Hydrazones
|2 NLM
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|a poly-N-isopropylacrylamide
|2 NLM
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|a 25189-55-3
|2 NLM
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|a Alsop, Richard J
|e verfasserin
|4 aut
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|a Scotti, Andrea
|e verfasserin
|4 aut
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|a Bleuel, Markus
|e verfasserin
|4 aut
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|a Rheinstädter, Maikel C
|e verfasserin
|4 aut
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|a Richtering, Walter
|e verfasserin
|4 aut
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| 700 |
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|a Hoare, Todd
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1999
|g 34(2018), 4 vom: 30. Jan., Seite 1601-1612
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:34
|g year:2018
|g number:4
|g day:30
|g month:01
|g pages:1601-1612
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|u http://dx.doi.org/10.1021/acs.langmuir.7b03664
|3 Volltext
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