Novel anti-suprabasin antibodies may contribute to the pathogenesis of neuropsychiatric systemic lupus erythematosus

Novel anti-suprabasin antibodies may contribute to the pathogenesis of neuropsychiatric systemic lupus erythematosus

Copyright © 2017 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 193(2018) vom: 10. Aug., Seite 123-130
1. Verfasser: Ichinose, Kunihiro (VerfasserIn)
Weitere Verfasser: Ohyama, Kaname, Furukawa, Kaori, Higuchi, Osamu, Mukaino, Akihiro, Satoh, Katsuya, Nakane, Shunya, Shimizu, Toshimasa, Umeda, Masataka, Fukui, Shoichi, Nishino, Ayako, Nakajima, Hideki, Koga, Tomohiro, Kawashiri, Shin-Ya, Iwamoto, Naoki, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, Yoshida, Mari, Kuroda, Naotaka, Kawakami, Atsushi
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2018
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Cerebrospinal fluid Immune complexes Neuropsychiatric systemic lupus erythematosus Suprabasin Antigen-Antibody Complex Antigens, Differentiation Autoantibodies Autoantigens mehr... Neoplasm Proteins SBSN protein, human
Beschreibung
Zusammenfassung:Copyright © 2017 Elsevier Inc. All rights reserved.
Neuropsychiatric systemic lupus erythematosus (NPSLE) is often difficult to diagnose and distinguish from other diseases, because no NPSLE-specific antibodies have been identified. We developed a novel proteomic strategy for identifying and profiling antigens in immune complexes in the cerebrospinal fluid (CSF), and applied this strategy to 26 NPSLE patients. As controls, we also included 25 SLE patients without neuropsychiatric manifestations (SLE), 15 with relapsing remitting multiple sclerosis (MS) and 10 with normal pressure hydrocephalus (NPH). We identified immune complexes of suprabasin (SBSN) in the CSF of the NPSLE group. The titer of anti-SBSN antibodies was significantly higher in the CSF of the NPSLE group compared to those of the SLE, MS and NPH groups. Microarray data showed that the senescence and autophagy pathways were significantly changed in astrocytes exposed to anti-SBSN antibodies. Our findings indicate that SBSN could be a novel autoantibody for the evaluation of suspected NPSLE
Beschreibung:Date Completed 27.08.2019
Date Revised 27.08.2019
published: Print-Electronic
CommentIn: Clin Immunol. 2018 Aug;193:131-132. - PMID 29197637
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2017.11.006