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231225s2018 xx |||||o 00| ||eng c |
| 024 |
7 |
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|a 10.1016/j.clim.2017.10.014
|2 doi
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| 028 |
5 |
2 |
|a pubmed24n0925.xml
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|a (DE-627)NLM277759803
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|a (NLM)29108854
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|a (PII)S1521-6616(17)30269-3
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Zhang, Leifang
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a SOCS-1 ameliorates smoke inhalation-induced acute lung injury through inhibition of ASK-1 activity and DISC formation
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| 264 |
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1 |
|c 2018
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 05.07.2019
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| 500 |
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|a Date Revised 05.07.2019
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a Copyright © 2017 Elsevier Inc. All rights reserved.
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|a Smoke inhalation leads to acute lung injury (ALI), a devastating clinical problem associated with high mortality. Suppressor of cytokine signaling-1 (SOCS-1) is a negative regulator of apoptosis and pro-inflammatory cytokine signaling, two major contributors to the pathogenesis of ALI. We have found that SOCS-1 protects lung epithelial cells from smoke-induced apoptosis through two mechanisms. One is that SOCS-1 enhances degradation of ASK-1 and diminishes cleavage of pro-caspase-3 to repress smoke-triggered apoptosis in lung epithelial cells. The other is that SOCS-1 represses smoke-triggered DISC formation through altering TRADD-caspase-8 interaction rather than TNFR-1-TRADD interaction or TNFR-1-TRAF-2 interaction. In conclusion, SOCS-1 relieves smoke inhalation-induced lung injury by repressing ASK-1 and DISC-mediated epithelium apoptosis
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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4 |
|a Apoptosis signal-regulating kinase-1
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| 650 |
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4 |
|a Death-inducing signaling complex
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| 650 |
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4 |
|a Small airway epithelial cells
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| 650 |
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4 |
|a Smoke-induced ALI
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| 650 |
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4 |
|a Suppressor of cytokine signaling-1
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| 650 |
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7 |
|a Death Domain Receptor Signaling Adaptor Proteins
|2 NLM
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| 650 |
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|a SOCS1 protein, human
|2 NLM
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| 650 |
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7 |
|a Suppressor of Cytokine Signaling 1 Protein
|2 NLM
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| 650 |
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7 |
|a TNF Receptor-Associated Death Domain Protein
|2 NLM
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| 650 |
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7 |
|a TNF Receptor-Associated Factor 2
|2 NLM
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| 650 |
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7 |
|a MAP Kinase Kinase Kinase 5
|2 NLM
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| 650 |
|
7 |
|a EC 2.7.11.25
|2 NLM
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| 650 |
|
7 |
|a MAP3K5 protein, human
|2 NLM
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| 650 |
|
7 |
|a EC 2.7.11.25
|2 NLM
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| 650 |
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|a CASP8 protein, human
|2 NLM
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| 650 |
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7 |
|a EC 3.4.22.-
|2 NLM
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| 650 |
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7 |
|a Caspase 8
|2 NLM
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| 650 |
|
7 |
|a EC 3.4.22.-
|2 NLM
|
| 700 |
1 |
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|a Xu, Chenming
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ma, Yating
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhu, Kairui
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Xiaoming
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shi, Qiwen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Su, Weike
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhao, Hang
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 191(2018) vom: 08. Juni, Seite 94-99
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:191
|g year:2018
|g day:08
|g month:06
|g pages:94-99
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| 856 |
4 |
0 |
|u http://dx.doi.org/10.1016/j.clim.2017.10.014
|3 Volltext
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|d 191
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