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231225s2017 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.7b02954
|2 doi
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|a pubmed25n0924.xml
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|a DE-627
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|a eng
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1 |
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|a Tsao, Nadia H
|e verfasserin
|4 aut
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|a Model for Microcapsule Drug Release with Ultrasound-Activated Enhancement
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|c 2017
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|a Text
|b txt
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 25.01.2019
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|a Date Revised 25.01.2019
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Microbubbles and microcapsules of silane-polycaprolactone (SiPCL) have been filled with a fluorescent acridium salt (lucigenin) as a model for a drug-loaded delivery vehicle. The uptake and delivery were studied and compared with similar microbubbles and microcapsules of silica/mercaptosilica (S/M/S). Positively charged lucigenin was encapsulated through an electrostatic mechanism, following a Type I Langmuir isotherm as expected, but with an additional multilayer uptake that leads to a much higher loading for the SiPCL system (∼280 μg/2.4 × 109 microcapsules compared with ∼135 μg/2.4 × 109 microcapsules for S/M/S). Whereas the lucigenin release from the S/M/S bubbles and capsules loaded below the solubility limit is consistent with diffusion from a monolithic structure, the SiPCL structures show distinct release patterns; the Weibull function predicts a general trend for diffusion from normal Euclidean space at short times tending toward diffusion out of fractal spaces with increasing time. As a slow release system, the dissolution time (Td) increases from 1 to 2 days for the S/M/S and for the low concentration, loaded SiPCl vehicles to ∼10 days for the high loaded microcapsules. However, Td can be reduced on insonation to 2 days, indicating the potential to gain control over the local enhanced release with ultrasound. This was tested for a docetaxel model and its effect on C4-2B prostate cancer cells, showing improved cell toxicity for concentrations below the normal EC50 in solution
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|a Journal Article
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|a Capsules
|2 NLM
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|a Silicon Dioxide
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|a 7631-86-9
|2 NLM
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|a Hall, Elizabeth A H
|e verfasserin
|4 aut
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1985
|g 33(2017), 45 vom: 14. Nov., Seite 12960-12972
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:33
|g year:2017
|g number:45
|g day:14
|g month:11
|g pages:12960-12972
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|u http://dx.doi.org/10.1021/acs.langmuir.7b02954
|3 Volltext
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