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NLM277298180 |
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DE-627 |
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231225s2018 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2017.10.008
|2 doi
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|a pubmed25n0924.xml
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|a (DE-627)NLM277298180
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|a (NLM)29061446
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|a (PII)S1521-6616(17)30641-1
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Ishioka-Takei, Eriko
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Increased proportion of a CD38highIgD+ B cell subset in peripheral blood is associated with clinical and immunological features in patients with primary Sjögren's syndrome
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| 264 |
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|c 2018
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 18.03.2019
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|a Date Revised 18.03.2019
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a Copyright © 2017 Elsevier Inc. All rights reserved.
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|a We investigated the correlation between the increased proportion of peripheral B cell subsets and clinical and immunological features in primary Sjögren's syndrome (pSS). We found that the proportion of CD19+ B cells was significantly increased in pSS as compared with HC and was correlated with serum IgG levels. Moreover, in vitro IgG production by CD19+ B cells was significantly increased in pSS and was positively and significantly correlated with serum IgG levels. FACS analysis revealed that the proportions of peripherally CD38highIgD+ B cells and CD38highIgD- B cells were significantly increased in pSS. In addition, the proportion of CD38highIgD+ B cells positively correlated with ESSDAI scores and serum levels of IgG, anti-Ro/SSA and anti-La/SSB antibodies while that of CD38highIgD- B cells showed no correlation with these parameters. Our data suggest that increased proportion of CD38highIgD+ B cells in pSS is involved in IgG overproduction including autoantibodies, and correlates with disease progression
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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| 650 |
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4 |
|a Autoantibodies
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| 650 |
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4 |
|a B cell
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| 650 |
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4 |
|a CD38
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| 650 |
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4 |
|a ESSDAI
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| 650 |
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4 |
|a IgD
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| 650 |
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4 |
|a IgG
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| 650 |
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4 |
|a Sjögren's syndrome
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| 650 |
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|a Antibodies, Antinuclear
|2 NLM
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| 650 |
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|a Antigens, CD19
|2 NLM
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| 650 |
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|a Immunoglobulin D
|2 NLM
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| 650 |
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7 |
|a Immunoglobulin G
|2 NLM
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| 650 |
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7 |
|a SS-A antibodies
|2 NLM
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| 650 |
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7 |
|a SS-B antibodies
|2 NLM
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| 650 |
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7 |
|a ADP-ribosyl Cyclase 1
|2 NLM
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| 650 |
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7 |
|a EC 3.2.2.6
|2 NLM
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| 700 |
1 |
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|a Yoshimoto, Keiko
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Suzuki, Katsuya
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Nishikawa, Ayumi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yasuoka, Hidekata
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yamaoka, Kunihiro
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Takeuchi, Tsutomu
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 187(2018) vom: 01. Feb., Seite 85-91
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:187
|g year:2018
|g day:01
|g month:02
|g pages:85-91
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| 856 |
4 |
0 |
|u http://dx.doi.org/10.1016/j.clim.2017.10.008
|3 Volltext
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 187
|j 2018
|b 01
|c 02
|h 85-91
|