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231225s2018 xx |||||o 00| ||eng c |
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|a 10.5713/ajas.17.0178
|2 doi
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|a pubmed25n0924.xml
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|a (NLM)29059723
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|a DE-627
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|e rakwb
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|a eng
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|a Uzzaman, Md Rasel
|e verfasserin
|4 aut
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| 245 |
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|a Whole-genome association and genome partitioning revealed variants and explained heritability for total number of teats in a Yorkshire pig population
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|c 2018
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status PubMed-not-MEDLINE
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|a OBJECTIVE: The study was designed to perform a genome-wide association (GWA) and partitioning of genome using Illumina's PorcineSNP60 Beadchip in order to identify variants and determine the explained heritability for the total number of teats in Yorkshire pig
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|a METHODS: After screening with the following criteria: minor allele frequency, MAF≤0.01; Hardy-Weinberg equilibrium, HWE≤0.000001, a pair-wise genomic relationship matrix was produced using 42,953 single nucleotide polymorphisms (SNPs). A genome-wide mixed linear model-based association analysis (MLMA) was conducted. And for estimating the explained heritability with genome- or chromosome-wide SNPs the genetic relatedness estimation through maximum likelihood approach was used in our study
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|a RESULTS: The MLMA analysis and false discovery rate p-values identified three significant SNPs on two different chromosomes (rs81476910 and rs81405825 on SSC8; rs81332615 on SSC13) for total number of teats. Besides, we estimated that 30% of variance could be explained by all of the common SNPs on the autosomal chromosomes for the trait. The maximum amount of heritability obtained by partitioning the genome were 0.22±0.05, 0.16±0.05, 0.10±0.03 and 0.08±0.03 on SSC7, SSC13, SSC1, and SSC8, respectively. Of them, SSC7 explained the amount of estimated heritability along with a SNP (rs80805264) identified by genome-wide association studies at the empirical p value significance level of 2.35E-05 in our study. Interestingly, rs80805264 was found in a nearby quantitative trait loci (QTL) on SSC7 for the teat number trait as identified in a recent study. Moreover, all other significant SNPs were found within and/or close to some QTLs related to ovary weight, total number of born alive and age at puberty in pigs
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|a CONCLUSION: The SNPs we identified unquestionably represent some of the important QTL regions as well as genes of interest in the genome for various physiological functions responsible for reproduction in pigs
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|a Journal Article
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|a Genome Partitioning
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|a Genome-wide Association Study
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|a Pig
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| 650 |
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4 |
|a Teat Number
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| 700 |
1 |
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|a Park, Jong-Eun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lee, Kyung-Tai
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cho, Eun-Seok
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Choi, Bong-Hwan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kim, Tae-Hun
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Asian-Australasian journal of animal sciences
|d 1998
|g 31(2018), 4 vom: 05. Apr., Seite 473-479
|w (DE-627)NLM098195883
|x 1011-2367
|7 nnns
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| 773 |
1 |
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|g volume:31
|g year:2018
|g number:4
|g day:05
|g month:04
|g pages:473-479
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|u http://dx.doi.org/10.5713/ajas.17.0178
|3 Volltext
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|d 31
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|h 473-479
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