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231225s2018 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2017.10.005
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|a pubmed25n0923.xml
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|a eng
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| 100 |
1 |
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|a Lee, Chen-Chen
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Overexpression of Notch ligand Delta-like-1 by dendritic cells enhances their immunoregulatory capacity and exerts antiallergic effects on Th2-mediated allergic asthma in mice
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|c 2018
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 18.03.2019
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|a Date Revised 10.12.2019
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2017 Elsevier Inc. All rights reserved.
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|a Dendritic cells (DCs) are professional antigen-presenting cells, and Notch ligand Delta-like-1 (DLL1) on DCs was implicated in type 1T helper (Th1) differentiation. In this study, we produced genetically engineered bone marrow-derived DCs that expressed DLL1 (DLL1-DCs) by adenoviral transduction. DLL1-DCs exerted a fully mature phenotype, and had positive effects on expression levels of interleukin (IL)-12 and costimulatory molecules. Coculture of allogeneic T cells with ovalbumin (OVA)-pulsed DLL1-DCs enhanced T cell proliferative responses and promoted Th1 cell differentiation. Furthermore, adoptive transfer of OVA-stimulated DLL1-DCs into asthmatic mice alleviated the cardinal features of allergic asthma, including immunoglobulin E (IgE) production, airway hyperresponsiveness (AHR), airway inflammation, and production of Th2-type cytokines. Notably, enhanced levels of the Th1-biased IgG2a response and interferon (IFN)-γ production were observed in these mice. Taken together, these data indicate that DLL1-DCs promoted Th1 cell development to alter the Th1/Th2 ratio and ameliorate Th2-mediated allergic asthma in mice
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Adenovirus
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|a Allergic asthma
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|a Delta-like-1
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|a Dendritic cells
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|a Th1
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|a Th2
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|a Calcium-Binding Proteins
|2 NLM
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|a Dlk1 protein, mouse
|2 NLM
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|a Intercellular Signaling Peptides and Proteins
|2 NLM
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| 650 |
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|a Interleukin-12
|2 NLM
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| 650 |
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|a 187348-17-0
|2 NLM
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| 650 |
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|a Immunoglobulin E
|2 NLM
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| 650 |
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|a 37341-29-0
|2 NLM
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| 650 |
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|a Ovalbumin
|2 NLM
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| 650 |
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|a 9006-59-1
|2 NLM
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| 700 |
1 |
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|a Lin, Chu-Lun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Leu, Sy-Jye
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lee, Yueh-Lun
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 187(2018) vom: 15. Feb., Seite 58-67
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnas
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| 773 |
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|g volume:187
|g year:2018
|g day:15
|g month:02
|g pages:58-67
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|u http://dx.doi.org/10.1016/j.clim.2017.10.005
|3 Volltext
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