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231225s2017 xx |||||o 00| ||eng c |
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|a 10.1002/adma.201704136
|2 doi
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|a pubmed24n0923.xml
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|a (DE-627)NLM277041910
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|a (NLM)29035426
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|a DE-627
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|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Guo, Zhao
|e verfasserin
|4 aut
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| 245 |
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|a Synthesis of BSA-Coated BiOIBi2 S3 Semiconductor Heterojunction Nanoparticles and Their Applications for Radio/Photodynamic/Photothermal Synergistic Therapy of Tumor
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|c 2017
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 18.07.2018
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|a Date Revised 01.10.2020
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|a published: Print-Electronic
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|a Citation Status PubMed-not-MEDLINE
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|a © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a Developing an effective theranostic nanoplatform remains a great challenge for cancer diagnosis and treatment. Here, BiOIBi2 S3 @BSA (bovine serum albumin) semiconductor heterojunction nanoparticles (SHNPs) for triple-combination radio/photodynamic/photothermal cancer therapy and multimodal computed tomography/photoacoustic (CT/PA) bioimaging are reported. On the one hand, SHNPs possess strong X-ray attenuation capability since they contain high-Z elements, and thus they are anticipated to be a very competent candidate as radio-sensitizing materials for radiotherapy enhancement. On the other hand, as a semiconductor, the as-prepared SHNPs offer an extra approach for reactive oxygen species generation based on electron-hole pair under the irradiation of X-ray through the photodynamic therapy process. This X-ray excited photodynamic therapy obviously has better penetration depth in bio-tissue. What's more, the SHNPs also possess well photothermal conversion efficiency for photothermal therapy, because Bi2 S3 is a thin band semiconductor with strong near-infrared absorption that can cause local overheat. In vivo tumor ablation studies show that synergistic radio/photodynamic/photothermal therapy achieves more significant therapeutic effect than any single treatment. In addition, with the strong X-ray attenuation and high near-infrared absorption, the as-obtained SHNPs can also be applied as a multimodal contrast agent in CT/PA imaging
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|a Journal Article
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4 |
|a bismuth oxyiodide
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| 650 |
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4 |
|a photodynamic therapy
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| 650 |
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4 |
|a photothermal therapy
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| 650 |
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4 |
|a radiotherapy
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| 650 |
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4 |
|a semiconductors
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| 700 |
1 |
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|a Zhu, Shuang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yong, Yuan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Xiao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Dong, Xinghua
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Du, Jiangfeng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xie, Jiani
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Qing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gu, Zhanjun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhao, Yuliang
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 29(2017), 44 vom: 16. Nov.
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
1 |
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|g volume:29
|g year:2017
|g number:44
|g day:16
|g month:11
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|u http://dx.doi.org/10.1002/adma.201704136
|3 Volltext
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