Homoeologous exchanges cause extensive dosage-dependent gene expression changes in an allopolyploid crop

Bibliographische Detailangaben
Veröffentlicht in:	The New phytologist. - 1979. - 217(2018), 1 vom: 31. Jan., Seite 367-377
1. Verfasser:	Lloyd, Andrew (VerfasserIn)
Weitere Verfasser:	Blary, Aurélien, Charif, Delphine, Charpentier, Catherine, Tran, Joseph, Balzergue, Sandrine, Delannoy, Etienne, Rigaill, Guillem, Jenczewski, Eric
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2018
Zugriff auf das übergeordnete Werk:	The New phytologist
Schlagworte:	Journal Article Brassica napus (Rapeseed) copy number variation gene expression homoeologous exchanges meiotic recombination polyploidy

Beschreibung
Zusammenfassung:	© 2017 The Authors. New Phytologist © 2017 New Phytologist Trust. Structural variation is a major source of genetic diversity and an important substrate for selection. In allopolyploids, homoeologous exchanges (i.e. between the constituent subgenomes) are a very frequent type of structural variant. However, their direct impact on gene content and gene expression had not been determined. Here, we used a tissue-specific mRNA-Seq dataset to measure the consequences of homoeologous exchanges (HE) on gene expression in Brassica napus, a representative allotetraploid crop. We demonstrate that expression changes are proportional to the change in gene copy number triggered by the HEs. Thus, when homoeologous gene pairs have unbalanced transcriptional contributions before the HE, duplication of one copy does not accurately compensate for loss of the other and combined homoeologue expression also changes. These effects are, however, mitigated over time. This study sheds light on the origins, timing and functional consequences of homeologous exchanges in allopolyploids. It demonstrates that the interplay between new structural variation and the resulting impacts on gene expression, influences allopolyploid genome evolution
Beschreibung:	Date Completed 27.07.2018 Date Revised 09.04.2022 published: Print-Electronic Citation Status MEDLINE
ISSN:	1469-8137
DOI:	10.1111/nph.14836