Gain-of-function variants in NLRP1 protect against the development of diabetic kidney disease NLRP1 inflammasome role in metabolic stress sensing?

Gain-of-function variants in NLRP1 protect against the development of diabetic kidney disease : NLRP1 inflammasome role in metabolic stress sensing?

Copyright © 2017 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 187(2018) vom: 15. Feb., Seite 46-49
1. Verfasser: Soares, Jaine L S (VerfasserIn)
Weitere Verfasser: Fernandes, Fernanda Pereira, Patente, Thiago Andrade, Monteiro, Maria B, Parisi, Maria C, Giannella-Neto, Daniel, Corrêa-Giannella, Maria L, Pontillo, Alessandra
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2018
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Diabetic kidney disease Inflammasome NLRP1 SNPs Type 1 diabetes Adaptor Proteins, Signal Transducing Apoptosis Regulatory Proteins Blood Glucose mehr... Glycation End Products, Advanced Inflammasomes NLR Proteins NLRP1 protein, human Serum Albumin Glycated Serum Albumin
Beschreibung
Zusammenfassung:Copyright © 2017 Elsevier Inc. All rights reserved.
Although inflammasome plays a well-known role in animal models of renal injury, limited studies in humans are available, and its participation in diabetic kidney disease (DKD) remains unknown. Aim of this study was to elucidate the contribution of inflammasome genetics in the development of DKD in type-1 diabetes (T1D). The association of functional variants in inflammasome genes with DKD was assessed by multivariate analysis in a retrospective and in a prospective cohort. NLRP1 rs2670660 and rs11651270 polymorphisms were significantly associated with a decrease risk to develop DKD (padj<0.01), and rs11651270 also with a lower risk of new renal events during follow-up (padj=0.01). Supporting these findings, diabetes metabolites (glycated albumin and high glucose) were able to modulate NLRP1 expression. This study is the first to suggest a protective role of NLRP1 in DKD, highlighting an emerging role of NLRP1 as a homeostatic factor against metabolic stress
Beschreibung:Date Completed 18.03.2019
Date Revised 07.12.2022
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2017.10.003