CD4+ CD52lo T-cell expression contributes to the development of systemic lupus erythematosus

CD4+ CD52lo T-cell expression contributes to the development of systemic lupus erythematosus

Copyright © 2017 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 187(2018) vom: 01. Feb., Seite 50-57
1. Verfasser: Umeda, Masataka (VerfasserIn)
Weitere Verfasser: Koga, Tomohiro, Ichinose, Kunihiro, Igawa, Takashi, Sato, Tomohito, Takatani, Ayuko, Shimizu, Toshimasa, Fukui, Shoichi, Nishino, Ayako, Horai, Yoshiro, Hirai, Yasuko, Kawashiri, Shin-Ya, Iwamoto, Naoki, Aramaki, Toshiyuki, Tamai, Mami, Nakamura, Hideki, Yamamoto, Kazuo, Abiru, Norio, Origuchi, Tomoki, Ueki, Yukitaka, Kawakami, Atsushi
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2018
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't CD52 Systemic lupus erythematosus T cells Antibodies, Antinuclear Autoantibodies CCL17 protein, human CCR8 protein, human CD52 Antigen mehr... CD52 protein, human Chemokine CCL17 Immunoglobulin G Receptors, CCR8
Beschreibung
Zusammenfassung:Copyright © 2017 Elsevier Inc. All rights reserved.
The cell-surface glycoprotein CD52 is widely expressed in lymphocytes. CD4+CD52hi T cells are functioning suppressor CD4+T cells. We investigated the role of the immune regulation of CD4+CD52 T cells in systemic lupus erythematosus (SLE). CD4+CD52lo T cells were increased in SLE patients, in positive correlation with SLEDAI, anti-ds-DNA antibody, and IgG concentration. Circulating follicular helper-like T cells (Tfh-like cells) were also increased in SLE, in positive correlation with CD4+CD52lo T cells. Chemokine receptor 8 (CCR8) expression in CD4+CD52lo T cells was increased. In vitro experiments using CD4 T cells of SLE patients showed that thymus and activation-regulated chemokine (TARC), a ligand of CCR8, contributed to the development of CD4+CD52hi T cells into CD4+CD52lo T cells. Our findings suggest that CD4+CD52lo T-cell upregulation is involved in the production of pathogens by autoantibodies, and TARC may contribute to the development of SLE through an aberrant induction of CD4+CD52lo T cells
Beschreibung:Date Completed 18.03.2019
Date Revised 18.03.2019
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2017.10.004