Nanoengineered Colloidal Inks for 3D Bioprinting

Nanoengineered hydrogels offer the potential to design shear-thinning bioinks for three-dimensional (3D) bioprinting. Here, we have synthesized colloidal bioinks composed of disk-shaped two-dimensional (2D) nanosilicates (Laponite) and poly(ethylene glycol) (PEG). The addition of Laponite reinforces...

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Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1999. - 34(2018), 3 vom: 23. Jan., Seite 917-925
1. Verfasser: Peak, Charles W (VerfasserIn)
Weitere Verfasser: Stein, Jean, Gold, Karli A, Gaharwar, Akhilesh K
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2018
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Colloids Hydrogels Silicates Polyethylene Glycols 3WJQ0SDW1A laponite D703131383
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520 |a Nanoengineered hydrogels offer the potential to design shear-thinning bioinks for three-dimensional (3D) bioprinting. Here, we have synthesized colloidal bioinks composed of disk-shaped two-dimensional (2D) nanosilicates (Laponite) and poly(ethylene glycol) (PEG). The addition of Laponite reinforces the PEG network and increases viscosity, storage modulus, and network stability. PEG-Laponite hydrogels display shear-thinning and self-recovery characteristics due to rapid internal phase rearrangement. As a result, a range of complex patterns can be printed using PEG-Laponite bioinks. The 3D bioprinted structure has similar mechanical properties compared to the as-casted structure. In addition, encapsulated cells within the PEG-Laponite bioink show high viability after bioprinting. Overall, this study introduces a new class of PEG-Laponite colloidal inks for bioprinting and cell delivery 
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700 1 |a Stein, Jean  |e verfasserin  |4 aut 
700 1 |a Gold, Karli A  |e verfasserin  |4 aut 
700 1 |a Gaharwar, Akhilesh K  |e verfasserin  |4 aut 
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