|
|
|
|
| LEADER |
01000caa a22002652 4500 |
| 001 |
NLM276214196 |
| 003 |
DE-627 |
| 005 |
20250222085752.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231225s2017 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1016/j.clim.2017.09.021
|2 doi
|
| 028 |
5 |
2 |
|a pubmed25n0920.xml
|
| 035 |
|
|
|a (DE-627)NLM276214196
|
| 035 |
|
|
|a (NLM)28951327
|
| 035 |
|
|
|a (PII)S1521-6616(17)30417-5
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Hanley, Patrick
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Circulating B cells in type 1 diabetics exhibit fewer maturation-associated phenotypes
|
| 264 |
|
1 |
|c 2017
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 13.12.2017
|
| 500 |
|
|
|a Date Revised 10.06.2019
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.
|
| 520 |
|
|
|a Although autoantibodies have been used for decades as diagnostic and prognostic markers in type 1 diabetes (T1D), further analysis of developmental abnormalities in B cells could reveal tolerance checkpoint defects that could improve individualized therapy. To evaluate B cell developmental progression in T1D, immunophenotyping was used to classify circulating B cells into transitional, mature naïve, mature activated, and resting memory subsets. Then each subset was analyzed for the expression of additional maturation-associated markers. While the frequencies of B cell subsets did not differ significantly between patients and controls, some T1D subjects exhibited reduced proportions of B cells that expressed transmembrane activator and CAML interactor (TACI) and Fas receptor (FasR). Furthermore, some T1D subjects had B cell subsets with lower frequencies of class switching. These results suggest circulating B cells exhibit variable maturation phenotypes in T1D. These phenotypic variations may correlate with differences in B cell selection in individual T1D patients
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Research Support, N.I.H., Extramural
|
| 650 |
|
4 |
|a Research Support, Non-U.S. Gov't
|
| 650 |
|
4 |
|a B lymphocytes
|
| 650 |
|
4 |
|a FasR
|
| 650 |
|
4 |
|a TACI
|
| 650 |
|
4 |
|a Type 1 diabetes
|
| 700 |
1 |
|
|a Sutter, Jennifer A
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Goodman, Noah G
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Du, Yangzhu
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Sekiguchi, Debora R
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Meng, Wenzhao
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Rickels, Michael R
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Naji, Ali
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Luning Prak, Eline T
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 183(2017) vom: 04. Okt., Seite 336-343
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
|
| 773 |
1 |
8 |
|g volume:183
|g year:2017
|g day:04
|g month:10
|g pages:336-343
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1016/j.clim.2017.09.021
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_11
|
| 912 |
|
|
|a GBV_ILN_24
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 183
|j 2017
|b 04
|c 10
|h 336-343
|