The roles of AaMIXTA1 in regulating the initiation of glandular trichomes and cuticle biosynthesis in Artemisia annua

The roles of AaMIXTA1 in regulating the initiation of glandular trichomes and cuticle biosynthesis in Artemisia annua

© 2017 The Authors. New Phytologist © 2017 New Phytologist Trust.

Bibliographische Detailangaben
Veröffentlicht in:The New phytologist. - 1979. - 217(2018), 1 vom: 06. Jan., Seite 261-276
1. Verfasser: Shi, Pu (VerfasserIn)
Weitere Verfasser: Fu, Xueqing, Shen, Qian, Liu, Meng, Pan, Qifang, Tang, Yueli, Jiang, Weimin, Lv, Zongyou, Yan, Tingxiang, Ma, Yanan, Chen, Minghui, Hao, Xiaolong, Liu, Pin, Li, Ling, Sun, Xiaofen, Tang, Kexuan
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2018
Zugriff auf das übergeordnete Werk:The New phytologist
Schlagworte:Journal Article AaMIXTA1 Artemisia annua L. artemisinin epidermal cuticle glandular secretory trichomes (GSTs) Artemisinins Plant Proteins Transcription Factors 9RMU91N5K2
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500 |a Date Revised 21.03.2022 
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520 |a The glandular secretory trichomes (GSTs) on Artemisia annua leaves have the capacity to secrete and store artemisinin, a compound which is the most effective treatment for uncomplicated malaria. An effective strategy to improve artemisinin content is therefore to increase the density of GSTs in A. annua. However, the formation mechanism of GSTs remains poorly understood. To explore the mechanisms of GST initiation in A. annua, we screened myeloblastosis (MYB) transcription factor genes from a GST transcriptome database and identified a MIXTA transcription factor, AaMIXTA1, which is expressed predominantly in the basal cells of GST in A. annua. Overexpression and repression of AaMIXTA1 resulted in an increase and decrease, respectively, in the number of GSTs as well as the artemisinin content in transgenic plants. Transcriptome analysis and cuticular lipid profiling showed that AaMIXTA1 is likely to be responsible for activating cuticle biosynthesis. In addition, dual-luciferase reporter assays further demonstrated that AaMIXTA1 could directly activate the expression of genes related to cuticle biosynthesis. Taken together, AaMIXTA1 regulated cuticle biosynthesis and prompted GST initiation without any abnormal impact on the morphological structure of the GSTs and so provides a new way to improve artemisinin content in this important medicinal plant 
650 4 |a Journal Article 
650 4 |a AaMIXTA1 
650 4 |a Artemisia annua L. 
650 4 |a artemisinin 
650 4 |a epidermal cuticle 
650 4 |a glandular secretory trichomes (GSTs) 
650 7 |a Artemisinins  |2 NLM 
650 7 |a Plant Proteins  |2 NLM 
650 7 |a Transcription Factors  |2 NLM 
650 7 |a artemisinin  |2 NLM 
650 7 |a 9RMU91N5K2  |2 NLM 
700 1 |a Fu, Xueqing  |e verfasserin  |4 aut 
700 1 |a Shen, Qian  |e verfasserin  |4 aut 
700 1 |a Liu, Meng  |e verfasserin  |4 aut 
700 1 |a Pan, Qifang  |e verfasserin  |4 aut 
700 1 |a Tang, Yueli  |e verfasserin  |4 aut 
700 1 |a Jiang, Weimin  |e verfasserin  |4 aut 
700 1 |a Lv, Zongyou  |e verfasserin  |4 aut 
700 1 |a Yan, Tingxiang  |e verfasserin  |4 aut 
700 1 |a Ma, Yanan  |e verfasserin  |4 aut 
700 1 |a Chen, Minghui  |e verfasserin  |4 aut 
700 1 |a Hao, Xiaolong  |e verfasserin  |4 aut 
700 1 |a Liu, Pin  |e verfasserin  |4 aut 
700 1 |a Li, Ling  |e verfasserin  |4 aut 
700 1 |a Sun, Xiaofen  |e verfasserin  |4 aut 
700 1 |a Tang, Kexuan  |e verfasserin  |4 aut 
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773 1 8 |g volume:217  |g year:2018  |g number:1  |g day:06  |g month:01  |g pages:261-276 
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