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231225s2018 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2017.09.010
|2 doi
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|a pubmed25n0919.xml
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|a (DE-627)NLM275883922
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|a (NLM)28917721
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|a (PII)S1521-6616(17)30653-8
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Vadasz, Z
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Low levels of the immunoregulator Semaphorin 4D (CD100) in sera of HIV patients
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|c 2018
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 05.07.2019
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|a Date Revised 05.07.2019
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2017 Elsevier Inc. All rights reserved.
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|a INTRODUCTION: Semaphorin-4D (CD100), generated by CD4/CD8 T-cells and its receptor on B cells - CD72, play a role in immune regulation. Both have soluble forms - sCD100/sCD72
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|a METHODS: sCD100 and sCD72 levels were determined by ELISA (MyBioSource, USA)
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|a RESULTS: 28 chronic HIV patients and 50 matched healthy volunteers participated in our study. Before treatment, CD4 T-cells counts were 267 ± 216 cells/mcl and viral load (VL) was 586,675 ± 1897,431 copies/ml. Two years following HAART, CD4 T-cells counts rose to 475 ± 264 cells/mcl and VL dropped to 2050 ± 10,539 copies/ml. CD8 T-cells counts were stable. sCD72 levels prior (4.13 ± 2.03 ng/ml) and following HAART (3.53 ± 2.01 ng/ml) were similar to control levels (4.51 ± 2.66 ng/ml). sCD100 levels before (40.47 ± 31.4 ng/ml) and following HAART (37.68 ± 29.44 ng/ml) were significantly lower compared to controls (99.67 ± 36.72 ng/ml) despite the significant increase in CD4 T-cells counts
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|a CONCLUSIONS: The permanent low levels of the immunoregulator sCD100 suggest a role for CD100 in the immune dysfunction and T cells exhaustion of HIV
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|a Journal Article
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|a CD4 T cells
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| 650 |
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|a CD8 T cells
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| 650 |
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|a HAART
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|a HIV
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| 650 |
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|a Soluble CD100/SEMA4D
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|a Soluble CD72
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| 650 |
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|a Antigens, CD
|2 NLM
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|a Antigens, Differentiation, B-Lymphocyte
|2 NLM
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|a CD100 antigen
|2 NLM
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| 650 |
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|a CD72 protein, human
|2 NLM
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| 650 |
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|a Semaphorins
|2 NLM
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| 700 |
1 |
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|a Elbirt, D
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Radian, S
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bezalel-Rosenberg, S
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mahlab-Guri, K
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Toubi, E
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Asher, I
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sthoeger, Z
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 191(2018) vom: 15. Juni, Seite 88-93
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnas
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| 773 |
1 |
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|g volume:191
|g year:2018
|g day:15
|g month:06
|g pages:88-93
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2017.09.010
|3 Volltext
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|a GBV_USEFLAG_A
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|a SYSFLAG_A
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|a GBV_NLM
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 191
|j 2018
|b 15
|c 06
|h 88-93
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