Antibodies targeting BTLA or TIM-3 enhance HIV-1 specific T cell responses in combination with PD-1 blockade

Antibodies targeting BTLA or TIM-3 enhance HIV-1 specific T cell responses in combination with PD-1 blockade

Copyright © 2017 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 183(2017) vom: 04. Okt., Seite 167-173
1. Verfasser: Grabmeier-Pfistershammer, Katharina (VerfasserIn)
Weitere Verfasser: Stecher, Carmen, Zettl, Markus, Rosskopf, Sandra, Rieger, Armin, Zlabinger, Gerhard J, Steinberger, Peter
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2017
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't BTLA CD160 CTLA-4 Coinhibitory receptors HIV-1 Immune checkpoints LAG-3 PD-1 mehr... T cell exhaustion TIM-3 Antibodies, Blocking Antibodies, Monoclonal, Humanized Antigens, CD Antineoplastic Agents BTLA protein, human CD160 protein, human Cytokines GPI-Linked Proteins HAVCR2 protein, human HIV Antigens Hepatitis A Virus Cellular Receptor 2 Immunologic Factors Ipilimumab PDCD1 protein, human Programmed Cell Death 1 Receptor Receptors, Immunologic pembrolizumab DPT0O3T46P Lymphocyte Activation Gene 3 Protein
Beschreibung
Zusammenfassung:Copyright © 2017 Elsevier Inc. All rights reserved.
Persistent stimulation with antigens derived from viruses that establish chronic infections or tumour antigens results in the exhaustion of T cells. Coinhibitory receptors like PD-1 and CTLA-4 function as immune checkpoints on exhausted T cells. Blocking these molecules with antibodies improve immunity to cancer cells. Immune checkpoint inhibitors targeting other coinhibitory receptors might have a similar role in improving T cell function and thus also utility in cancer therapy. Using HIV-specific T cells as a model for exhaustion we have evaluated the capacity of antibodies targeting TIM-3, BTLA, CD160, LAG-3 and CTLA-4 alone or in combination with a PD-1 antibody to enhance proliferation and cytokine production in response to Gag and Nef peptides. Antibodies targeting BTLA and TIM-3 enhanced CD8 T cell proliferation. Moreover, our results indicate that blocking BTLA and TIM-3 in combination with PD-1 might be especially effective in enhancing responses of exhausted human T cells
Beschreibung:Date Completed 21.11.2017
Date Revised 07.12.2022
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2017.09.002