One-Step Fast Synthesis of Nanoparticles for MRI Coating Chemistry as the Key Variable Determining Positive or Negative Contrast

One-Step Fast Synthesis of Nanoparticles for MRI : Coating Chemistry as the Key Variable Determining Positive or Negative Contrast

Iron oxide nanomaterial is a typical example of a magnetic resonance imaging probe for negative contrast. It has also been shown how this nanomaterial can be synthesized for positive contrast by modification of the composition and size of the core. However, the role of the organic coating in the rel...

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Bibliographische Detailangaben
Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1992. - 33(2017), 39 vom: 03. Okt., Seite 10239-10247
1. Verfasser: Pellico, Juan (VerfasserIn)
Weitere Verfasser: Ruiz-Cabello, Jesús, Fernández-Barahona, Irene, Gutiérrez, Lucía, Lechuga-Vieco, Ana V, Enríquez, Jose A, Morales, M Puerto, Herranz, Fernando
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2017
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Journal Article Research Support, Non-U.S. Gov't
Beschreibung
Zusammenfassung:Iron oxide nanomaterial is a typical example of a magnetic resonance imaging probe for negative contrast. It has also been shown how this nanomaterial can be synthesized for positive contrast by modification of the composition and size of the core. However, the role of the organic coating in the relaxometric properties is largely unexplored. Here, maghemite nanoparticles with either excellent positive or very good negative contrast performance are obtained by modifying coating thickness while the core is kept unchanged. Different nanoparticles with tailored features as contrast agent according to the coating layer thickness have been obtained in a single-step microwave-driven synthesis by heating at different temperatures. A comprehensive analysis is conducted of how the composition and structure of the coating affects the final magnetic, relaxometric, and imaging performance. These results show how the organic coating plays a fundamental role in the intrinsic relaxometric parameters of iron oxide-based contrast media
Beschreibung:Date Completed 31.07.2018
Date Revised 31.07.2018
published: Print-Electronic
Citation Status PubMed-not-MEDLINE
ISSN:1520-5827
DOI:10.1021/acs.langmuir.7b01759