|
|
|
|
| LEADER |
01000caa a22002652 4500 |
| 001 |
NLM275529657 |
| 003 |
DE-627 |
| 005 |
20250222062705.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231225s2017 xx |||||o 00| ||chi c |
| 024 |
7 |
|
|a 10.3760/cma.j.issn.0578-1310.2017.09.007
|2 doi
|
| 028 |
5 |
2 |
|a pubmed25n0918.xml
|
| 035 |
|
|
|a (DE-627)NLM275529657
|
| 035 |
|
|
|a (NLM)28881511
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a chi
|
| 100 |
1 |
|
|a Zhou, N
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Role of IgG antibody to galactose-deficient IgA1 in children with IgA nephropathy
|
| 264 |
|
1 |
|c 2017
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 01.04.2019
|
| 500 |
|
|
|a Date Revised 01.04.2019
|
| 500 |
|
|
|a published: Print
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a Objective: In order to learn the serum level of galactose-deficient IgA1 (GdIgA1), IgG antibody to galactose-deficient IgA1(GdIgA1-IgG) and the clinical role of them in IgA nephropathy(IgAN) children. Method: We compared blood levels of GdIgA1, GdIgA1-IgG in 33 children with IgAN, 38 children with other renal disease (including focal segmental glomerular nephritis, minimal change disease, Alport syndrome and thin basement membrane nephropathy) as disease controls, 35 healthy children as normal controls with enzyme-linked immunosorbent assay(ELISA). Twenty-four-hour urine protein content and Lee's pathological classification were collected in IgAN cases. The difference among the three groups were examined by analysis of variance. The specificity and sensitivity of GdIgA1, GdIgA1-IgG to IgA nephropathy were evaluated by ROC curve.The correlations were analyzed by correlation analysis among GdIgA1, GdIgA1-IgG and urine protein content and pathological classification . All statistical analyses were performed by SPSS 18.0. P value of <0.05 was considered statistically significant. Result: The levels of GdIgA1 and GdIgA1-IgG significantly elevated in children with IgAN compared to disease controls and normal controls. GdIgA1(mg/L): 1.728±0.456, 1.123±0.461, 1.410±0.905 (F=15.04, P<0.001); GdIgA1-IgG(g/L): 1.299±0.499, 1.111±0.549, 0.628±0.142 (F=76.96, P<0.001). Area under the curve of ROC of GdIgA1 between IgAN and normal controls was 0.765, with specificity 0.943 and sensitivity 0.697, while the area under the curve of GdIgA1-IgG was 0.969, with specificity 0.971 and sensitivity 0.939.The blood level of GdIgA1-IgG was mildly correlated with both 24-hour urine protein(r=0.364, ) and renal pathological grading(r=0.392) in children with IgAN. Conclusion: The levels of GdIgA1 and GdIgA1-IgG significantly elevated in children with IgAN compared to disease controls and normal controls. GdIgA1-IgG had higher sensitivity in distinguishing IgAN from normal controls, GdIgA1-IgG was mildly correlated with 24-hour urine protein volume and pathological grading in children with IgAN
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Child
|
| 650 |
|
4 |
|a Glomerulonephritis, IGA
|
| 650 |
|
4 |
|a Glycosylation
|
| 650 |
|
4 |
|a Immunoglobulin A
|
| 650 |
|
4 |
|a Immunoglobulin G
|
| 650 |
|
7 |
|a Immunoglobulin A
|2 NLM
|
| 650 |
|
7 |
|a Immunoglobulin G
|2 NLM
|
| 650 |
|
7 |
|a Galactose
|2 NLM
|
| 650 |
|
7 |
|a X2RN3Q8DNE
|2 NLM
|
| 700 |
1 |
|
|a Zhang, H
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Liu, X R
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Sun, Q
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Meng, Q
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Chen, Z
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Shen, Y
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Zhonghua er ke za zhi = Chinese journal of pediatrics
|d 1960
|g 55(2017), 9 vom: 02. Sept., Seite 663-667
|w (DE-627)NLM136249191
|x 0578-1310
|7 nnns
|
| 773 |
1 |
8 |
|g volume:55
|g year:2017
|g number:9
|g day:02
|g month:09
|g pages:663-667
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.3760/cma.j.issn.0578-1310.2017.09.007
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_11
|
| 912 |
|
|
|a GBV_ILN_20
|
| 912 |
|
|
|a GBV_ILN_22
|
| 912 |
|
|
|a GBV_ILN_24
|
| 912 |
|
|
|a GBV_ILN_31
|
| 912 |
|
|
|a GBV_ILN_39
|
| 912 |
|
|
|a GBV_ILN_40
|
| 912 |
|
|
|a GBV_ILN_50
|
| 912 |
|
|
|a GBV_ILN_61
|
| 912 |
|
|
|a GBV_ILN_65
|
| 912 |
|
|
|a GBV_ILN_69
|
| 912 |
|
|
|a GBV_ILN_70
|
| 912 |
|
|
|a GBV_ILN_72
|
| 912 |
|
|
|a GBV_ILN_120
|
| 912 |
|
|
|a GBV_ILN_130
|
| 912 |
|
|
|a GBV_ILN_227
|
| 912 |
|
|
|a GBV_ILN_244
|
| 912 |
|
|
|a GBV_ILN_285
|
| 912 |
|
|
|a GBV_ILN_294
|
| 912 |
|
|
|a GBV_ILN_350
|
| 912 |
|
|
|a GBV_ILN_665
|
| 912 |
|
|
|a GBV_ILN_813
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 55
|j 2017
|e 9
|b 02
|c 09
|h 663-667
|