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231225s2017 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2017.08.019
|2 doi
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|a pubmed24n0917.xml
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|a (DE-627)NLM275393704
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|a (NLM)28867253
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|a (PII)S1521-6616(17)30375-3
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Zhou, Zejun
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Estrogen decreases tight junction protein ZO-1 expression in human primary gut tissues
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1 |
|c 2017
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 13.12.2017
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|a Date Revised 13.11.2018
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2017 Elsevier Inc. All rights reserved.
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|a Females have a higher prevalence of most autoimmune diseases; however, the mechanism is unknown. In this study, we examined the expression of tight junction protein zonula occludens 1 (ZO-1) and estrogen receptor (ER)-α/β in human primary gut tissues by immunohistochemistry, immunofluorescence and qPCR. The expression of ZO-1 and ER-β but not ER-α was present in both male and female gut tissues. There was no sex difference in ER-β expression, but ZO-1 expression was decreased in females compared to males. In vitro, estrogen treatment decreased ZO-1 mRNA and protein expression, ZO-1 promoter activity, IL-6 production, and NF-κB activation in human primary gut tissues or the Caco-2 cells, but increased the ER-β expression in Caco-2 cells. Consistently, plasma IL-6 levels in females were reduced relative to males in vivo. Our finding indicates that estrogen may play a role in gut tight junction expression and permeability
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Research Support, U.S. Gov't, Non-P.H.S.
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| 650 |
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|a Research Support, Non-U.S. Gov't
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| 650 |
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|a Sex differences
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|a ZO-1
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|a estrogen
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|a gut tissues
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|a Estrogen Receptor alpha
|2 NLM
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| 650 |
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|a Estrogen Receptor beta
|2 NLM
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| 650 |
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|a Interleukin-6
|2 NLM
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| 650 |
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|a NF-kappa B
|2 NLM
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| 650 |
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|a TJP1 protein, human
|2 NLM
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| 650 |
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|a Zonula Occludens-1 Protein
|2 NLM
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| 650 |
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|a Estradiol
|2 NLM
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| 650 |
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|a 4TI98Z838E
|2 NLM
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| 650 |
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|a Keratins
|2 NLM
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| 650 |
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|a 68238-35-7
|2 NLM
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| 700 |
1 |
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|a Zhang, Lumin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ding, Miao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Luo, Zhenwu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yuan, Shao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bansal, Meena B
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gilkeson, Gary
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lang, Ren
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jiang, Wei
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 183(2017) vom: 01. Okt., Seite 174-180
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:183
|g year:2017
|g day:01
|g month:10
|g pages:174-180
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2017.08.019
|3 Volltext
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|d 183
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|h 174-180
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