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231225s2018 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2017.08.015
|2 doi
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|a pubmed24n0917.xml
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|a (DE-627)NLM275361519
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|a (NLM)28863969
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|a (PII)S1521-6616(17)30145-6
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Kielsen, Katrine
|e verfasserin
|4 aut
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|a Soluble Interleukin-7 receptor levels and risk of acute graft-versus-host disease after allogeneic haematopoietic stem cell transplantation
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|c 2018
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 18.03.2019
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|a Date Revised 18.03.2019
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2017 Elsevier Inc. All rights reserved.
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|a Interleukin-7 is a cytokine essential for T cell homeostasis. IL-7 binds to cellular IL-7 receptors in competition with a soluble form of the receptor (sIL-7Rα). We hypothesized that altered sIL-7Rα levels may cause adverse outcomes in patients undergoing HSCT. In parallel, we investigated the impact of the IL-7Rα SNP rs6897932, which has been associated with release of IL-7R. The sIL-7Rα levels decreased during HSCT (from 114ng/ml before to 48ng/ml at day +14 (P<0.0001)). This pattern was inversely mirrored by IL-7. The IL-7/sIL-7Rα ratio at day +14 was significantly higher in patients developing grades II-IV aGVHD (OR=4.3, P=0.026). Furthermore, donor carriage of the rs6897932 T allele was associated with reduced sIL-7Rα levels, increased risk of grades II-IV aGVHD (OR=2.4, P=0.055) and increased transplant-related mortality (CC=4.5%, CT=21.4% and TT=27.3%, P=0.0037). In conclusion, this study suggests an impact of sIL-7Rα levels and rs6897932 donor genotype on alloreactivity and outcome after HSCT
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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| 650 |
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|a Acute graft-versus-host disease
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| 650 |
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|a Allogeneic HSCT
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| 650 |
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|a IL-7Rα SNPs
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| 650 |
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|a Soluble IL-7R
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| 650 |
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|a IL7 protein, human
|2 NLM
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| 650 |
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|a IL7R protein, human
|2 NLM
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| 650 |
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|a Interleukin-7
|2 NLM
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| 650 |
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|a Interleukin-7 Receptor alpha Subunit
|2 NLM
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| 700 |
1 |
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|a Shamim, Zaiba
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Thiant, Stephanie
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Faucher, Sylvie
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Decker, Wendy
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Christensen, Ib Jarle
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ryder, Lars Peter
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yakoub-Agha, Ibrahim
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Müller, Klaus
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 187(2018) vom: 15. Feb., Seite 26-32
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:187
|g year:2018
|g day:15
|g month:02
|g pages:26-32
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2017.08.015
|3 Volltext
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